Results 101 to 110 of about 2,396,893 (309)

HIV-1 Tropism Determines Different Mutation Profiles in Proviral DNA. [PDF]

PLoS ONE, 2015
In order to establish new infections HIV-1 particles need to attach to receptors expressed on the cellular surface. HIV-1 particles interact with a cell membrane receptor known as CD4 and subsequently with another cell membrane molecule known as a co ...
Sieberth Nascimento-Brito, Jean Paulo Zukurov, Juliana T Maricato, Angela C Volpini, Anna Christina M Salim, Flávio M G Araújo, Roney S Coimbra, Guilherme C Oliveira, Fernando Antoneli, Luiz Mário R Janini   +9 more
doaj   +1 more source

KLHL12 promotes non-lysine ubiquitination of the dopamine receptors D-4.2 and D-4.4, but not of the ADHD-associated D-4.7 variant [PDF]

, 2015
Dopamine D-4 Receptor Polymorphism : The dopamine D-4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit ...
Lintermans, Béatrice, Rondou, Pieter, Skieterska, Kamila, Van Craenenbroeck, Kathleen   +3 more
core   +4 more sources

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide [PDF]

, 2004
BACKGROUND: For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission.
A Robert Neurath, A Stone, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, B Conde-Petit, C Berset, C Ma, CD Pilcher, CD Rizzuto, CW Davis, DH Schwartz, DJ Bacon, E Poyrazoglu, EA Merritt, EG Cormier, G Zhang, H Blaak, H Brown, J Moore, JM Johnson, JP Moore, L Hammar, L Wu, M Hsu, M Seguchi, MA Skinner, N DeTommasi, N Mahmood, N Mahmood, Nathan Strick, P Langley, P Suphaphiphat, P Tomasik, P Westervelt, P Westervelt, PD Kwong, PJ Kraulis, Q Hu, Q Zhao, R Pantophlet, R Shattock, R Stute, R Weiss, RJ Shattock, RJ Shattock, RN Fichorova, RN Fichorova, RS Veazey, S Garg, S Gartner, S Laal, S Liu, S-T Hsu, SH Xiang, TC Pierson, UNAIDS, VJ Tomazic-Jezic, WC Greene, WR Yao, Y Van Herrewege, Yun-Yao Li   +66 more
core   +3 more sources

Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy

OncoTarget, 2015
Introduction Somatostatin receptors (SSTR) are widely distributed in well-differentiated neuroendocrine neoplasms (NEN) and serve as primary targets for diagnostics and treatment.
D. Kaemmerer, Tina Träger, Maike Hoffmeister, B. Sipos, M. Hommann, J. Sänger, S. Schulz, A. Lupp   +7 more
semanticscholar   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

eLife
The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T Schafer, Raymond F Pauszek III, Martin Gustavsson, Tracy M Handel, David P Millar   +4 more
doaj   +1 more source

Envelope-receptor interactions in Nipah virus pathobiology. [PDF]

, 2007
Nipah (NiV) and Hendra (HeV) viruses are members of the newly defined Henipavirus genus of the Paramyxoviridae. Nipah virus (NiV) is an emergent paramyxovirus that causes fatal encephalitis in up to 70% of infected patients, and there is increasing ...
Lee, Benhur
core   +1 more source

Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors

World Journal of Gastroenterology, 2008
To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and SDF-1beta".
Carl C, Schimanski, Peter R, Galle, Markus, Moehler   +2 more
openaire   +2 more sources

Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7 [PDF]

Biochemical Pharmacology, 2013
The chemokine CXCL12 and its shared seven-transmembrane receptors CXCR4 and CXCR7 regulate diseases including cancer, atherosclerosis, autoimmunity, and HIV infection, making these molecules promising drug targets. These molecules also control key processes in normal development and physiology, suggesting the need to selectively modulate CXCR4 and/or ...
Anna, Ehrlich, Paramita, Ray, Kathryn E, Luker, Elias J, Lolis, Gary D, Luker   +4 more
openaire   +2 more sources