Results 271 to 280 of about 2,396,893 (309)

Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies. [PDF]

PLoS One
Haq BU, Sofi S, Qayoom H, Jan N, Jan A, Aljasir M, Ahmad I, Almilabairy A, Ahmad F, Alshehri B, Mir MA.   +10 more
europepmc   +1 more source

The meningeal-cerebellar axis: a new perspective on cerebellar development. [PDF]

Cell Mol Life Sci
Al-Sayyar A, Salvon L, Haidar N, Schult P, Kassem O, Rua R, Romano A.   +6 more
europepmc   +1 more source

CXCR4-targeted therapy in lung cancer: plerixafor as a promising antimetastatic agent. [PDF]

Front Pharmacol
Ramalingam PS, Afzal M, Babu MA, Rekha MM, Sahoo S, Pandey SN, Goyal K, Hussain MS, Gupta G, Balakrishnan P, Arumugam S.   +10 more
europepmc   +1 more source

The CCL17/CCL22-CCR4 Axis in Pain Pathogenesis: A Comprehensive Review of Immune-Mediated Mechanisms and Therapeutic Opportunities. [PDF]

Mol Neurobiol
Hasheminia A, Mann S, Liblik K, El-Diasty M.   +3 more
europepmc   +1 more source

Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics. [PDF]

Sci Rep
Ho KKY, Buschhaus JM, Zhang A, Cutter AC, Humphries BA, Luker GD.   +5 more
europepmc   +1 more source

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The chemokine receptors CXCR4 and CXCR3 in cancer

Current Oncology Reports, 2009
Chemokines comprise a superfamily of at least 46 cytokines that were initially described based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed migration of leukocytes to sites of inflammation or injury. In addition to mediating cellular migration, chemokine/chemokine receptor pairs have been shown to affect many ...
A. Fulton
semanticscholar   +3 more sources

Configurationally Restricted Bismacrocyclic CXCR4 Receptor Antagonists

Journal of Medicinal Chemistry, 2006
A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favorable binding to acetate via a bidentate chelation that can be related to the proposed interaction with ...
Gina C, Valks, Graeme, McRobbie, Elizabeth A, Lewis, Timothy J, Hubin, Tina M, Hunter, Peter J, Sadler, Christophe, Pannecouque, Erik, De Clercq, Stephen J, Archibald   +8 more
openaire   +2 more sources

Cbl Regulates CXCR4-Mediated Chemotaxis and CXCR4 Receptor Internalization.

Blood, 2004
Abstract CXCL12-induced and CXCR4-mediated chemotaxis plays a critical role in the trafficking of lymphocytes, which modulates inflammatory and immune responses. The CXCR4 receptor is down-modulated by its ligand CXCL12, which has been shown to inhibit HIV entry into the cells.
Ramesh K. Ganju, Aaron Z. Fernandis, Appakkudal R. Anand, Heather C. Lane   +3 more
openaire   +1 more source

Chemokine receptor CXCR4: Role in gastrointestinal cancer

Critical Reviews in Oncology/Hematology, 2013
Chemokines (CK)s, small proinflammatory chemoattractant cytokines that bind to specific G-protein coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184).
Lombardi L., Tavano F., Morelli F., Latiano T. P., Di Sebastiano P., Maiello E.   +5 more
openaire   +2 more sources