Results 281 to 290 of about 2,396,893 (309)

CXCR4: chemokine receptor extraordinaire

Immunological Reviews, 2000
Current investigations show that chemokine receptor CXCR4 is functionally expressed on a multitude of tissues and cell types, including different leukocyte subsets, hematopoietic progenitor cells and non-hematopoietic cells such as endothelial and epithelial cells.
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CXCR4 chemokine receptor antagonists: perspectives in SCLC

Expert Opinion on Investigational Drugs, 2009
Small-cell lung cancer (SCLC) is a particularly aggressive form of lung cancer characterized by early and widespread metastases and the ability to rapidly develop resistance against chemotherapeutic agents. Tumor cell migration and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokine receptors and ...
Jan A, Burger, David J, Stewart
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Mapping the CXCR4 receptor on breast cancer cells

Biomaterials, 2015
The CXCR4 receptor triggers cell migration and, in breast cancer, promotes metastasis. To date, the dynamic assembly of CXCR4 on the cell surface as a mediator of receptor binding is not well characterized. The objective of this work is to quantify the density, spatial organization, and magnitude of binding of the CXCR4 receptor on live metastatic ...
Wang, Biran, Guo, Peng, Auguste, Debra
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CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment

Journal of Cancer Research and Clinical Oncology, 2023
CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors (GPCRs) superfamily and is specific for CXC chemokine ligand 12 (CXCL12, also known as SDF-1), which makes CXCL12/CXCR4 axis. CXCR4 interacts with its ligand, triggering downstream signaling pathways that influence cell proliferation chemotaxis, migration, and gene ...
Shunshun, Bao, Mohammad, Darvishi, Ali, H Amin, Maysoon T, Al-Haideri, Indrajit, Patra, Khadisha, Kashikova, Irfan, Ahmad, Fahad, Alsaikhan, Zahraa Haleem, Al-Qaim, Moaed E, Al-Gazally, Bahman Abedi, Kiasari, Bahareh, Tavakoli-Far, Akmal A, Sidikov, Yasser Fakri, Mustafa, Reza, Akhavan-Sigari   +14 more
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Imaging agents for the chemokine receptor 4 (CXCR4)

Chemical Society Reviews, 2012
The interaction between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-1 (SDF-1, also known as CXCL12) is a natural regulatory process in the human body. However, CXCR4 over-expression is also found in diseases such as cancer, where it plays a role in, among others, the metastatic spread. For this reason it is an interesting biomarker
Kuil, J., Buckle, T., Leeuwen, F.W.B. van   +2 more
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CXCR4 Regulates B Cell Receptor Editing

2020
During B lymphopoiesis, B cell progenitors progress through alternating and mutually exclusive stages of clonal expansion and immunoglobulin (Ig) gene rearrangements. Great diversity is generated through the stochastic recombination of Ig gene segments encoding heavy and light chain variable domains.
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Small Molecule CXCR4 Chemokine Receptor Antagonists: Developing Drug Candidates

Current Medicinal Chemistry, 2007
Chemokine receptors are a target of growing interest for new therapeutic drugs, as their role in multiple disease states has been demonstrated. The CXCR4/ CXCL12 pairing has been implicated in HIV and cancer, as well as chronic inflammatory diseases, including asthma and rheumatoid arthritis.
Khan, Abid, Greenman, John, Archibald, Stephen J.   +2 more
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Expression of CXCR4 Receptors in Refractory Atypical Mediastinal Carcinoid

Clinical Nuclear Medicine, 2020
Abstract Primary neuroendocrine tumor of the mediastinum is a relatively rare entity. In metastatic/inoperable disease, therapeutic options are limited to cytotoxic chemotherapy in poorly differentiated tumors and peptide receptor radionuclide therapy in case of well-differentiated tumors.
Venkata Subramanian, Krishnaraju, Swayamjeet, Satapathy, Ashwani, Sood, Chandan Krushna, Das, Debajyoti, Chatterjee, Jaya, Shukla, Bhagwant Rai, Mittal   +6 more
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Soluble chemokine receptor CXCR4 is present in human sera

Analytical Biochemistry, 2011
A soluble form of the chemokine receptor CXCR4 was detected in human sera by isoelectric focusing and Western blotting. Sera of patients and normal subjects were analyzed using a panel of specific antibodies. Compared with controls, high levels of serum CXCR4 were found in patients with inflammatory bowel diseases. Serum CXCR4 levels in the majority of
Etienne, Malvoisin, Jean-Michel, Livrozet, Djamila, Makloufi, Nadine, Vincent   +3 more
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CXCR4 Receptor as a Promising Target for Oncolytic Drugs

Mini-Reviews in Medicinal Chemistry, 2008
There has been considerable in vivo evidence that chemokine receptor CXCR4 and its endogenous ligand CXCL12 modulate some important physiological and pathophysiological processes, including cancer metastasis, angiogenesis, invasion, growth and progression. In this review we elucidate key aspects of CXCL12-CXCR4 signaling system with emphasis on peptide-
Yan, Lavrovsky, Yan A, Ivanenkov, Konstantin V, Balakin, Darya A, Medvedeva, Alexandre V, Ivachtchenko   +4 more
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