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Cytokine Receptors and Signaling
2008Cytokines exert their effects after binding to specific cell surface receptors, which are composed of polypeptide chains. After the binding of the ligand to its receptor, there is an initiation of the signal transduction pathways culminating in the synthesis of new mRNA and protein synthesis, in most cases. Some of these pathways are unique targets for
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Cytokines: Interleukins and Their Receptors
1995Preface R. Kurzrock, M. Talpaz. Receptors for Hematopoietic Regulatory Cytokines: Overview of Structure and Function U. Gullberg, et al. Control of Thrombocytopoiesis: Current State of the Art R. Hoffman, M.W. Long. Interleukin-I and its Inhibitors: Implications for Disease Biology and Therapy Z. Estrov, et al. Interleukin- 2: Its Rationale and Role in
Razelle Kurzrock, Moshe Talpaz
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The Hematopoietic Cytokine Receptors
1996The growth and differentiation of hematopoietic stem cells to form the vast repertoire of mature blood cells that exists in vivo is orchestrated by an array of intercellular signals, mediated by cytokines in association with a complex stromal microenvironment.
Taisei Kinoshita +2 more
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Cytokine Receptors in the Brain
2008Abstract Cytokines, once thought to be specialized molecules of the immune system, are now being investigated also for their synaptic and inflammatory action on the central nervous system (CNS). These proteins and their receptors can be synthesized in the brain by glial and neuronal cells and contribute to two main types of action: modulation of ...
Bruno Conti +6 more
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1996
The cytokine receptors comprise an evolutionarily related group of molecules which fall into two distinct classes; namely the class I and class II cytokine receptors79–81 (Figs. 5-9). Class I comprises the cellular receptors for many interleukine (IL), such as those that regulate hematopoiesis, e.g., IL-382 IL-5, IL-11, granulocyte-macrophage colony ...
Ailsa G. Harpur, Andrew F. Wilks
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The cytokine receptors comprise an evolutionarily related group of molecules which fall into two distinct classes; namely the class I and class II cytokine receptors79–81 (Figs. 5-9). Class I comprises the cellular receptors for many interleukine (IL), such as those that regulate hematopoiesis, e.g., IL-382 IL-5, IL-11, granulocyte-macrophage colony ...
Ailsa G. Harpur, Andrew F. Wilks
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Cytokines and Cytokine Receptors: Principles of Action
2003Cytokines have become recognized as important mediators of the several aspects of inflammation. This introductory chapter will provide some basic aspects of cytokine biology including the functions of cytokines and their receptors. Given the brief nature of the chapter it is not possible to exhaustively review all of the cytokines and their biological ...
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