Results 81 to 90 of about 638,477 (202)

High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

eLife, 2017
NK cell education is the process through which chronic engagement of inhibitory NK cell receptors by self MHC-I molecules preserves cellular responsiveness. The molecular mechanisms responsible for NK cell education remain unclear.
Antoine Marçais, Marie Marotel, Sophie Degouve, Alice Koenig, Sébastien Fauteux-Daniel, Annabelle Drouillard, Heinrich Schlums, Sébastien Viel, Laurie Besson, Omran Allatif, Mathieu Bléry, Eric Vivier, Yenan Bryceson, Olivier Thaunat, Thierry Walzer   +14 more
doaj   +1 more source

Innate immune response in avian macrophages elicited by Chlamydia psittaci [PDF]

, 2015
Chlamydia psittaci is a gram-negative, obligate, intracellular bacterium, which mainly infects birds and mammals. Not much is known about innate immunity initiated by C. psittaci.
Lagae, Stefanie, Vanrompay, Daisy
core  

The Immune System [PDF]

, 1995
Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut, McCarthy, Donna O.   +1 more
core   +1 more source

Advanced cytokine-based immunotherapies: targeted cis-delivery strategies for enhanced anti-tumor efficacy and reduced toxicity

mAbs
First-generation cancer immunotherapies, such as high-dose interleukin-2 (IL-2), have demonstrated clinical efficacy, but are limited by significant systemic toxicities due to their broad expression of cytokine receptors.
Laurène Pousse, Amrita Manchala, Christian Klein, Laura Codarri Deak   +3 more
doaj   +1 more source

Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]

, 2015
Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core   +1 more source

ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. [PDF]

, 2015
Backgrounds and aims4-6 million people die of enteric infections each year. After invading intestinal epithelial cells, enteric bacteria encounter phagocytes.
Casanova, James E, Castillo, Victoria, Choudhury, Sarmistha Sinha, Das, Soumita, Eckmann, Lars, Elliott, Michael R, Ernst, Peter B, Fox, Sarah, Owen, Katherine A, Sarkar, Arup   +9 more
core  

Differential effects of age on chicken heterophil functional activation by recombinant chicken interleukin-2 [PDF]

, 2002
Kaiser, Pete, Kogut, Michael, Rothwell, Lisa   +2 more
core   +1 more source

NOD1/2 and the C-Type Lectin Receptors Dectin-1 and Mincle Synergistically Enhance Proinflammatory Reactions Both In Vitro and In Vivo

Journal of Inflammation Research, 2020
Amir I Tukhvatulin, Alina S Dzharullaeva, Alina S Erokhova, Dmitry V Scheblyakov, Boris S Naroditsky, Alexander L Gintsburg, Denis Y Logunov N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, RussiaCorrespondence: Amir I ...
Tukhvatulin AI, Dzharullaeva AS, Erokhova AS, Scheblyakov DV, Naroditsky BS, Gintsburg AL, Logunov DY   +6 more
doaj  

Phenotypic features of dendritic cells when using different modes of their stimulated maturation

Медицинская иммунология
Monocyte-derived dendritic cells (DCs) can be used for cell immunotherapy of cancer. In most cases, mature DCs, loaded with tumor-associated antigens, are used for immune therapy.
F. A. Fadeyev, A. D. Aleksandrova, A. S. Mogilenskikh   +2 more
doaj   +1 more source

Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. [PDF]

, 2019
BackgroundThe mechanisms whereby neuroinflammation negatively affects neuronal function in the hypothalamus are not clear. Our previous study determined that obesity-mediated chronic inflammation elicits sex-specific impairment in reproductive function ...
Coss, Djurdjica, Lainez, Nancy M
core   +1 more source