Results 81 to 90 of about 371,200 (274)
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Shuyi, A Name After Dendritic Cell-mediated Immunological Memory [PDF]
arXiv, 2019 Immunological memory is a fundamental theory of modern immunology, which is traditionally believed to be mediated only by B and T lymphocytes that recognize antigen epitopes in a receptor-restricted manner. During the last decade data accumulated to show that monocytes and macrophages, the two main initiators of innate immune response, also built up a "
arxiv
Scientific Reports, 2017 Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
A Collaboration Network Model Of Cytokine-Protein Network [PDF]
arXiv, 2007 Complex networks provide us a new view for investigation of immune systems. In this paper we collect data through STRING database and present a model with cooperation network theory. The cytokine-protein network model we consider is constituted by two kinds of nodes, one is immune cytokine types which can act as acts, other one is protein type which ...
arxiv
Artificial neural networks for disease trajectory prediction in the context of sepsis [PDF]
arXiv, 2020 The disease trajectory for clinical sepsis, in terms of temporal cytokine and phenotypic dynamics, can be interpreted as a random dynamical system. The ability to make accurate predictions about patient state from clinical measurements has eluded the biomedical community, primarily due to the paucity of relevant and high-resolution data.
arxiv
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source