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β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery

Advanced Science, EarlyView.
This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li, Haocheng Tang, Yiqing Mu, Shangyu Chen, Paul Edward Floreancig, Junmei Wang, Yixian Huang, Song Li   +7 more
wiley   +1 more source

From Evasion to Collapse: The Kinetic Cascade of TDP-43 and the Failure of Proteostasis. [PDF]

Int J Mol Sci
Jamerlan A, Hulme J.
europepmc   +1 more source

DEAD-box helicase gcDDX56 disrupts IRF3 nuclear import complex and promotes nuclear IRF3 degradation for enhancing GCRV replication. [PDF]

J Virol
Xiao LL, Chen Y, Zhang J, Xiao J, Feng H, Chang MX.   +5 more
europepmc   +1 more source

Combined use of Bumetanide and MGE cell transplantation alleviates neuropathic pain and its mechanism after spinal cord injury in mice. [PDF]

Front Immunol
Yu Y, Wang F.
europepmc   +1 more source

Clinicopathological and molecular features of solid pseudopapillary neoplasms: a retrospective series including a small subset of aggressive cases. [PDF]

Pathol Oncol Res
Comut E, Celik A, Uguz A, Ergun O, Baran S, Argon A, Nart D, Yilmaz F, Demirkan NC.   +8 more
europepmc   +1 more source

Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factors. [PDF]

Sci Adv
Ling N, Wu H, Zhang Y, Yao S, Liu F, Tang X, Xie T, Yuan Y, Wei X, Dai J, Chen W, Yan M, Wang Z, Peng T, Zhang Y, Wang H, Wu J, Ye M, Wu W.   +18 more
europepmc   +1 more source

Novel perspectives on extracellular vesicles in autoimmune diseases: immunogenicity, inflammation, and immune surveillance. [PDF]

J Clin Invest
Zhao Y, Lyu X, Wu X, Liu Y, Zhang N, Wei W, Liu ML.   +6 more
europepmc   +1 more source

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Nuclear and cytoplasmic estrogen receptors and progesterone receptors in breast cancer

European Journal of Cancer (1965), 1980
The relationships of cytoplasmic estrogen receptors occupied and free nuclear estrogen receptors and cytoplasmic progesterone receptors measured in a series of 83 primary breast carcinoma were examined. 83% of the patients were postmenopausal (range in age 30-86 years; average age 59.7). Preparation of the cytosol and nuclear fractions were described
R, Hähnel, R K, Partridge, L, Gavet, E, Twaddle, T, Ratajczak   +4 more
openaire   +2 more sources