Results 231 to 240 of about 166,825 (267)

Interaction of the activated cytoplasmic glucocorticoid hormone receptor complex with the nuclear envelope

Biochemistry, 1981
Highly purified activated cytoplasmic glucocorticoid hormone receptor binds with high affinity to sites in the nuclear envelope. Nuclear envelope fragments can be isolated from purified chromatin. They bind activated cytoplasmic glucocorticoid receptor with the same equilibrium constant as nuclear envelopes.
P, Smith, C, von Holt
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Estrogen receptors of human endometrium: characterization of nuclear and cytoplasmic forms and comparisons with rat uterine receptors

Journal of Steroid Biochemistry, 1980
Abstract A controlled trypsinization procedure is reported which results in more efficient solubilization of the nuclear estrogen receptor from human endometrium and rat uterine tissue than does extraction with high salt (0.4 M KCl) alone. The trypsin-liberated nuclear receptors in both species sediment at 3–4S on both high and low salt gradients ...
B S, Katzenellenbogen, N C, Lan, S K, Rutledge   +2 more
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Molecular pathways involved in the transport of nuclear receptors from the nucleus to cytoplasm

The Journal of Steroid Biochemistry and Molecular Biology, 2018
Nuclear receptors (NRs) are transcription regulators that direct the expression of many genes linked to cellular processes, such as proliferation, differentiation, and apoptosis. Additionally, some cellular events are also modulated by signaling pathways induced by NRs outside of the nucleus.
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A controlled pore glass bead assay for the measurement of cytoplasmic and nuclear glucocorticoid receptors

Journal of Steroid Biochemistry, 1985
An assay for the quantitation of cytoplasmic and nuclear glucocorticoid receptors in lymphoid tissue has been developed using controlled pore glass (CPG) beads. Soluble receptor--3H-steroid complex (cytosol or nuclear extract) is adsorbed quantitatively within the crevasses of porous glass beads.
G J, Gormley, V D, Hospelhorn, M K, Khan, E V, Jensen   +3 more
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Cytoplasmic and nuclear progesterone receptors in the guinea pig uterus.

Endocrinology, 1976
Although progesterone receptors have been studied in the uterine cytoplasm of many species, relatively little was known about the nuclear content of these binding proteins. In the present study, a nuclear progesterone receptor was deteced in the guinea pig uterus.
P D, Feil, C W, Bardin
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Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors

1994
Transcription factors, such as steroid receptors, must move through the cytoplasm to the nucleus and subsequently within the nucleus in a precisely targeted manner. Experiments carried out twenty years ago in intact cells exposed to metabolic inhibitors suggested that glucocorticoid receptors (GR) that have entered the nucleus (then defined as the low ...
William B. Pratt, Lawrence C. Scherrer
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Relationship of cytoplasmic and nuclear estrogen receptors and progesterone receptors in human breast cancer.

Cancer research, 1981
The qualitative and quantitative relationships between cytoplasmic estrogen receptors (ERC), total nuclear estrogen receptors (ERN), and cytoplasmic progesterone receptors (PGR) in 74 primary and 23 metastatic human breast cancer tissues were studied.
R, Romić-Stojković, S, Gamulin
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Cytoplasmic and nuclear estrogen and progesterone receptors in male breast cancer.

Cancer research, 1982
Cytoplasmic estrogen receptors were detected in 12 of 13 male breast cancer tumors. There was no significant correlation of receptor levels with the age of the patient, size and histological grading of the tumor, and stage and nodal involvement of the disease.
R J, Pegoraro, D, Nirmul, S M, Joubert
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Characterization of cytoplasmic progesterone receptors in rat granulosa cells. Evidence for nuclear translocation

Acta Endocrinologica, 1981
Abstract. The granulosa cells from immature rats were found to possess binding components for progestins. The physicochemical properties were determined. By sucrose gradient centrifugation, binding of [3H]R-5020 was observed in the 7S and 4S region of the gradient. Isoelectric focusing, however, revealed only one binding component (pH 5.9).
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Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1995
The effects of cyclosporin A (CsA), FK506 and rapamycin (Rapa) on the intracellular localization of a mutated rabbit progesterone receptor (PR) which lacks the main constitutive nuclear localization signal (NLS) (delta 638-642) and is cytoplasmic in the absence of progesterone (Prog), were assayed by indirect immunofluorescence in Lcl3 cells, a mouse L-
I, Jung-Testas, M C, Lebeau, M G, Catelli, E E, Baulieu   +3 more
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