Results 261 to 270 of about 299,088 (322)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Emergence, function, and therapeutic strategies to target the PD-1/PD-L1 immune checkpoint during pathogenic fungal infections. [PDF]

Virulence
Zheng X, He X, Song Z, Chen W, Liu F.
europepmc   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

The Nuclear Receptor Nurr1 Modulates the Expression and Activity of PPARγ in Human Pro-Inflammatory Macrophages. [PDF]

Scand J Immunol
Santana-Cisneros E, Solís-Barbosa MA, Segovia-Gamboa NC, Meraz-Ríos MA, González-Domínguez E, Hernández-Rivas R, Marrero-Rodríguez D, Sanchez-Torres C.   +7 more
europepmc   +1 more source

Rapid Arbitrary‐Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment

Advanced Science, EarlyView.
This study presents a novel microscopic imaging system capable of rapid, section‐free scanning of irregular tissue surfaces, delivering high sensitivity for detecting cancer cell clusters during intraoperative tumor margin assessment. Abstract Rapid and accurate intraoperative examination of tumor margins is crucial for precise surgical treatment, yet ...
Zhicheng Shao, Xiangwei Meng, Peifen Fu, Keer Huang, Xibei Chen, Yue Ying, Jun Li, Yuxin Zheng, Xiaolong Li, Hyeon Jeong Lee, Jingyi Feng, Yuexin Lu, Runping Cai, Xiongling Jiang, Qing Chen, Hong Zhang, Xiaoyong Man, Li Lin   +17 more
wiley   +1 more source

Decoding LAG3 activation: ubiquitination liberates immunosuppressive motif to license checkpoint function. [PDF]

Mol Biomed
Zhang T, Xie F, Zhou F.
europepmc   +1 more source

Sex hormone receptor signaling networks drive pancreatic solid-pseudopapillary neoplasm pathogenesis and therapy. [PDF]

Discov Oncol
Huang Y, He T.
europepmc   +1 more source

MetaboMiNR: An Online Tool to Analyze Label-Free Proteomic Experiments With a Focus on Metabolism and Nuclear Receptors.

Endocrinology
Saikali MF, Cummins CL.
europepmc   +1 more source

The Furan Fatty Acids 11M5 and 11D5 Can Act as Activators of Human Peroxisome Proliferator-Activated Receptor Gamma. [PDF]

Mol Nutr Food Res
Pospiech J, Caspi A, Vetter W, Kerem Z, Frank J, Kufer TA.   +5 more
europepmc   +1 more source

Arecoline upregulates CD155 expression to facilitate immune evasion in oral squamous cell carcinoma. [PDF]

J Immunother Cancer
Wang Q, Meng Y, Liu Y, Zhang S, Wang Y, Chen P, Xiang B, Zhou M, Gong Z, Zeng Z, Ge J, Xiong W.   +11 more
europepmc   +1 more source