Results 21 to 30 of about 299,088 (322)

Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics [PDF]

Endocrinology and Metabolism, 2021
Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways ...
Jong Hyeon Yoon, Ki-Sun Kwon
doaj   +1 more source

Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors

Biology, 2022
RNA-binding proteins (RBPs) with a low-complexity prion-like domain (PLD) can undergo aberrant phase transitions and have been implicated in neurodegenerative diseases such as ALS and FTD.
Amandeep Girdhar, Lin Guo
doaj   +1 more source

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway. [PDF]

, 2008
BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation.
A Herrmann, A Mahdavi, A Regev, A Regev, A Singh, A Verma, AD Sharrocks, Anna Dudka, B Alberts, C Priami, C Priami, Corrado Priami, D Gillespie, F Ciocchetta, I Lödige, I Swameye, J Bravo, J Fisher, J Heath, J ten Hoeve, John K Heath, K Rakesh, L Dematté, L Dematté, L Klampfer, M Calder, M Kwiatkowska, Maria Luisa Guerriero, ML Guerriero, ML Guerriero, ML Guerriero, N Underhill-Day, NC Reich, Nicholas Underhill-Day, P Heinrich, S Bhattacharya, T Yamamoto, WS Alexander   +37 more
core   +7 more sources

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]

, 2015
Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Martin, Kelsey C, Vashisht, Ajay, Wohlschlegel, James A   +5 more
core   +1 more source

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.

PLoS Pathogens, 2015
The innate immune system pattern recognition receptors (PRR) are the first line of host defenses recognizing the various pathogen- or danger-associated molecular patterns and eliciting defenses by regulating the production of pro-inflammatory cytokines ...
Dipanjan Dutta, Sujoy Dutta, Mohanan Valiya Veettil, Arunava Roy, Mairaj Ahmed Ansari, Jawed Iqbal, Leela Chikoti, Binod Kumar, Karen E Johnson, Bala Chandran   +9 more
doaj   +1 more source

The effects of treatment with melatonin on the ultrastructure of mouse leydig cells: a quantitative study [PDF]

Brazilian Journal of Biology, 2002
Both the presence of receptors for gonadal steroids in the pineal gland and in vitro observations of direct action of melatonin upon Leydig cells, inhibiting testosterone secretion, indicate a direct connection between pineal gland and gonadal function ...
C. A. REDINS, G. M. REDINS, J. C. NOVAES
doaj   +1 more source

Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. [PDF]

PLoS ONE, 2017
The GW182/TNRC6 family of proteins are central scaffolds that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes.
Jessica J Chaston, Alastair Gordon Stewart, Mary Christie   +2 more
doaj   +1 more source

Death receptor 5 expression is inversely correlated with prostate cancer progression. [PDF]

, 2014
Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic
Antonio-Andres, Gabriela, Bonavida, Benjamin, Gonzalez-Bonilla, Cesar, Hernandez-Cueto, Angeles, Hernandez-Cueto, Daniel, Huerta-Yepez, Sara, Jimenez-Gutierrez, Carlos, Mendoza-Marin, Marisela, Mora-Campos, Rosario, Sandoval-Mejia, Ana Lilia, Vega, Mario I   +10 more
core   +1 more source

Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients

Journal of Cancer Research and Clinical Oncology, 2020
Purpose Thyroid hormone receptors (THR) have manifold functions and are involved in the carcinogenesis of several tumor types. Within this study, we aimed to investigate the expression pattern (nuclear versus cytoplasmic) of the THR alpha and its impact ...
N. Ditsch, S. Heublein, U. Jeschke, C. Sattler, C. Kuhn, A. Hester, B. Czogalla, F. Trillsch, S. Mahner, J. Engel, D. Mayr, E. Schmoeckel   +11 more
semanticscholar   +1 more source

Evidence for the existence of an oligomeric, non-DNA-binding complex of the progesterone receptor in the cytoplasm

European Journal of Histochemistry, 2009
Steroid receptors are found as a hetero-oligomeric complex in cell extracts. Due to the dynamic interaction between receptor-associated proteins and receptors, it is difficult to study the oligomeric complex in living cells.
S Passinen, T Ylikomi
doaj   +1 more source