Results 21 to 30 of about 268,012 (165)

Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2011 Spandidos Publications Ltd.A vital function of the human placenta is to produce steroid hormones such as ...
Foster, H, Goumenou, A, Karteris, E, Rand-Weaver, M, Thomas, P, Zachariades, E   +5 more
core   +1 more source

Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
The constitutive androstane receptor (CAR) is a ligand/activator-dependent transactivation factor that resides in the cytoplasm and forms part of an as yet unidentified protein complex. Upon stimulation, CAR translocates into the nucleus where it modulates the transactivation of target genes.
Motoyoshi Suzuki, Yuichiro Kanno, Takayuki Nakahama, Yoshio Inouye   +3 more
openaire   +3 more sources

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism [PDF]

, 2019
A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation.
Albrechtsen, N., Araki, E., Batista, T., Cai, W., Cederquist, C., Damasio, M., Enerback, S., Gupta, M., Homan, E., Kahn, C., Mann, M., Ramirez, A., Sakaguchi, M., Singh, S., Steger, M., Wang, C.   +15 more
core   +2 more sources

Nuclear-Cytoplasmic Trafficking of NTF2, the Nuclear Import Receptor for the RanGTPase, Is Subjected to Regulation

PLoS ONE, 2012
NTF2 is a cytosolic protein responsible for nuclear import of Ran, a small Ras-like GTPase involved in a number of critical cellular processes, including cell cycle regulation, chromatin organization during mitosis, reformation of the nuclear envelope following mitosis, and controlling the directionality of nucleocytoplasmic transport.
Jacqueline B. Pierce, Shawn C. Chafe, Dev Mangroo   +2 more
openaire   +5 more sources

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients [PDF]

Brain, 2005
Spinal and bulbar muscular atrophy (SBMA) is an inherited adult onset motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR), affecting only males. The characteristic pathological finding is nuclear inclusions (NIs) consisting of mutant AR with an expanded polyQ in residual motor neurons, and in ...
Yuji Nakagomi, Masahiro Waza, Yasushi Kobayashi, Manabu Doyu, Mari Yoshida, Masahisa Katsuno, Yoshio Hashizume, Fumiaki Tanaka, Makoto Minamiyama, Hiroaki Adachi, Gen Sobue, Chen Sang, Akira Inukai   +12 more
openaire   +3 more sources

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]

, 2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R., Benvenuto, M, Bonanno, E, Cucchi, Danilo, DE SMAELE, Enrico, DI STEFANO, Enrica, Fantini, M, Frajese, Gv, Gulino, Alberto, Masuelli, Laura, Mattera, Rosanna, Modesti, A, Orlandi, A, Screpanti, Isabella   +13 more
core   +1 more source

A Study of Cytoplasmic and Nuclear Estrogen and Progestin Receptors in Gynecologic Neoplasms

Endocrinologia Japonica, 1987
A rapid method for simultaneous preparation of cytosol and nuclear estrogen (E) and progestin (P) receptors and their in vitro determination is described. The method was applied to several uterine or ovarian surgical specimens to evaluate their steroid hormone "dependence". The results suggest that low cytoplasmic E receptor levels (ERc) are associated
S. Takagi, Peter E. Schwartz, D. Phil, Neil J. MacLusky, Hideki Sakamoto, Hideki Sakamoto, Konbai Den, Frederick Naftolin   +7 more
openaire   +4 more sources

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

Nucleocytoplasmic transport: a thermodynamic mechanism

, 2009
The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion ...
Adam SA, Akey CW, Alber F, Bapteste E, Beck M, Becskei A, Ben‐Efraim I, Bickel T, Caspi Y, Catimel B, Cingolani G, Coppey M, Costa M, Cronshaw JM, Dange T, Denning DP, Devos D, Dixon M, Fanara P, Fradin C, Fradin C, Frey S, Grünwald D, Görlich D, Haldane JBS, Harreman MT, Henderson GP, Hinshaw JE, Hodel AE, Hu W, Hübner S, Jovanovic‐Talisman T, Kalab P, Kalderon D, Kapon R, Kobe B, Kopito RB, Kose S, Kotera I, Kubitscheck U, Kustanovich T, Köhler M, Lam MH, Lee SJ, Lyman SK, Mans BJ, Melcák I, Michael Elbaum, Michael WM, Miyamoto Y, Nachury MV, Naim B, Nakielny S, Newmeyer DD, Ossareh‐Nazari B, Pederson T, Pollard VW, Pyhtila B, Ribbeck K, Ribbeck K, Riddick G, Riddick G, Rihs HP, Robbins J, Ronen Benjamine Kopito, Rout MP, Salman H, Schmidt‐Zachmann MS, Schwartz TU, Shah S, Smith A, Stade K, Steggerda SM, Stein WD, Stoffler D, Strawn LA, Timney BL, Tokunaga M, Wen W, Yang Q, Yang W, Yang W, Zeitler B, Zilman A   +83 more
core   +2 more sources

Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]

, 2016
Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June, Gasser, Paul J, Hurley, Matthew M., Pickel, Virginia M.   +3 more
core   +2 more sources