Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]
, 2017 Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K. +4 more
core +2 more sources
Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance [PDF]
Molecular Cancer Research, 2017 Abstract Androgen receptor splice variants (AR-V) are implicated in resistance of prostate cancer to androgen-directed therapies. When expressed alone in cells, some AR-Vs (e.g., AR-V7) localize primarily to the nucleus, whereas others (e.g., AR-V1, AR-V4, and AR-V6) localize mainly to the cytoplasm.
Yang, Zhan +11 more
openaire +2 more sources
Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC
BMC Cancer, 2018 Background The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC).
Jan-Paul Gundlach +9 more
doaj +1 more source
A new procedure for the quantitation of nuclear and cytoplasmic androgen receptors.
Journal of Biological Chemistry, 1981 Experimental conditions for the measurement of prostatic androgen receptors occupied with unlabeled hormone are described. The assay allows quantitation of cytoplasmic and nuclear receptors occupied with unlabeled ligand by exchange with 17 beta-hydroxy-17 alpha-methyl [3H]estra-4,9,11-trien-3-one at 0 degrees C.
A. Traish, R. Müller, H. Wotiz
semanticscholar +3 more sources
NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
Nature Communications, 2017 Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear ...
Natalia Fili +7 more
doaj +1 more source
Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]
, 2016 Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June +3 more
core +2 more sources
Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients [PDF]
Brain, 2005 Spinal and bulbar muscular atrophy (SBMA) is an inherited adult onset motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR), affecting only males. The characteristic pathological finding is nuclear inclusions (NIs) consisting of mutant AR with an expanded polyQ in residual motor neurons, and in ...
Hiroaki, Adachi +12 more
openaire +2 more sources
BMC Cancer, 2006 Background Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in ...
Chen Liyong +9 more
doaj +1 more source
Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. [PDF]
PLoS ONE, 2015 Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula +4 more
doaj +1 more source
Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteins. [PDF]
PLoS Pathogens, 2015 The paramyxovirus matrix (M) protein is a molecular scaffold required for viral morphogenesis and budding at the plasma membrane. Transient nuclear residence of some M proteins hints at non-structural roles.
Mickey Pentecost +10 more
doaj +1 more source