Results 31 to 40 of about 268,012 (165)

Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target [PDF]

, 2020
It is now well-established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes.
Alshaker, Heba, Pchejetski, Dmitri, Thrower, Hannah   +2 more
core   +1 more source

Estrogen-mediated cytoplasmic and nuclear distribution of rat cardiovascular estrogen receptors. [PDF]

Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
We used either the synthetic estrogen R2858 (moxestrol) or estradiol-17 beta to characterize estrogen receptors in cytoplasmic (R2858) and nuclear (estradiol-17 beta) preparations from rat aorta and myocardium. Relative steroid specificity studies showed that only estrogens were effective inhibitors of R2858 or estradiol-17 beta binding to aortic and ...
Sydney A. Shain, Alan L. Lin
openaire   +3 more sources

Abnormal expression of p27kip1 protein in levator ani muscle of aging women with pelvic floor disorders – a relationship to the cellular differentiation and degeneration [PDF]

, 2001
BACKGROUND: Pelvic floor disorders affect almost 50% of aging women. An important role in the pelvic floor support belongs to the levator ani muscle. The p27/kip1 (p27) protein, multifunctional cyclin-dependent kinase inhibitor, shows changing expression
A Bukovsky, A Bukovsky, A Bukovsky, A Bukovsky, A Bukovsky, A Shafik, A Shafik, Antonin Bukovsky, BM-Praeger Stanulis, Bridgett Asbury, CY Chu, D Failes, F Beersiek, H Toyoshima, I Overlie, IT Bernstein, J Yeargin, Jeffrey B Brown, JO DeLancey, JO DeLancey, JQ Tian, JT Benson, K Kenton, K Polyak, L Guth, LT Bjornsdottir, LT Brubaker, M Jozwik, M Loden, M Sandri, MA Habiba, Maria Cekanova, Michael R Caudle, N Santoro, P Copas, P Kjolhede, PA Norton, PJ Blakeman, Pleas Copas, PP McKenzie, Robert F Elder, RV Lloyd, S Fujieda, SA Gilpin, SD Zabludoff, Stephanie B Cross, Stuart E Van Meter, Tamara Dassanayake, Y Katayose   +48 more
core   +4 more sources

Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways [PDF]

, 2012
The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners including the transport receptor TAP ...
Arnold, Aubert, Bachi, Bonifaci, Braun, Bryant, Chen, Chen, Copeland, Cullen, Darshan, Ellison, Ellison, Escudero-Paunetto, Faria, Fischer, Flach, Fontaine-Rodriguez, Fontoura, Fornerod, Fridell, Gerace, Gruffat, Grüter, Gustin, Gustin, Gustin, Han, Hardwicke, Hernandez, Hiriart, Hofemeister, Hutten, Johnson, Kambach, Koffa, Larralde, Lengyel, Lengyel, Li, Lilley, Long, Macaulay, Malik, Malik, McCarthy, Mears, Mears, Mears, Meyer, Michael, Nelson, Park, Pasdeloup, Pasquinelli, Pearson, Pellet, Petersen, Phelan, Piñol-Roma, Pollard, Pritchard, Rice, Rice, Rice, Rice, Rojas, Saavedra, Sandri-Goldin, Satterly, Schmitt, Sekulovich, Siomi, Smith, Soliman, Soliman, Souki, Strambio-De-Castillia, Strässer, Tsuji, Wagstaff, Wente, Zhi, Zhi   +83 more
core   +3 more sources

In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]

, 2009
FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD,
Chiocchia, Gilles, Schmitt, Alain, Tourneur, Léa   +2 more
core   +5 more sources

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Systems theory of Smad signaling

, 2006
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the ...
Alves, Alves, Barkai, Battogtokh, Brightman, Brown, Brown, Chacko, Chen, Colland, Conery, D.C. Clarke, Derynck, Dong, Fink, Funaba, Fung, Gardner, Hager, Haugh, Hoffmann, Huang, Inman, Inman, Jayaraman, Kawabata, Kholodenko, Kim, Lagna, Lander, Lee, Liu, M.D. Betterton, Massague, Massague, Massague, Nakao, Nakao, Nicolas, Nicolas, Park, Pasche, Pierreux, Poncelet, Remy, Schmierer, Schoeberl, Sedaghat, Shi, Shi, Subramanian, ten Dijke, Tewari, Tian, Tsukazaki, Vilar, von Dassow, Wu, X. Liu, Xu, Xu, Yamada, Zhang, Zi   +63 more
core   +1 more source

Future therapeutic strategies: Implications for Brk targeting [PDF]

, 2011
The official published article can be found at the link below - Copyright @ 2011 InTech. This Article has been provided by the Brunel Open Access Publishing Fund.Rajpal Burmi was supported by a Breast Cancer Campaign project ...
Burmi, RS, Harvey, AJ
core   +2 more sources

Death receptor 5 expression is inversely correlated with prostate cancer progression. [PDF]

, 2014
Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic
Antonio-Andres, Gabriela, Bonavida, Benjamin, Gonzalez-Bonilla, Cesar, Hernandez-Cueto, Angeles, Hernandez-Cueto, Daniel, Huerta-Yepez, Sara, Jimenez-Gutierrez, Carlos, Mendoza-Marin, Marisela, Mora-Campos, Rosario, Sandoval-Mejia, Ana Lilia, Vega, Mario I   +10 more
core   +1 more source

Androgen Induces a Switch from Cytoplasmic Retention to Nuclear Import of the Androgen Receptor [PDF]

Molecular and Cellular Biology, 2013
The androgen receptor (AR) has critical functions as a transcription factor in both normal and cancer cells, but the specific mechanisms that regulate its nuclear localization are not well defined. We found that an AR mutation commonly reported in prostate cancer generates an androgen-independent gain of function for nuclear import.
Adam Spencer, Li Ni, Leonard Shank, Chelsi J. Snow, Joshua B. Kelley, Bryce M. Paschal, Cristina T. Kesler, Ryan A. Llewellyn   +7 more
openaire   +3 more sources