Results 31 to 40 of about 285,475 (309)

Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus [PDF]

, 2004
The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established.
Galigniana, Mario Daniel, Harrell, Jennifer M., Ljungman, Mats, O´Hagen, Heather M., Pratt, William B.   +4 more
core   +1 more source

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients [PDF]

Brain, 2005
Spinal and bulbar muscular atrophy (SBMA) is an inherited adult onset motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR), affecting only males. The characteristic pathological finding is nuclear inclusions (NIs) consisting of mutant AR with an expanded polyQ in residual motor neurons, and in ...
Hiroaki, Adachi, Masahisa, Katsuno, Makoto, Minamiyama, Masahiro, Waza, Chen, Sang, Yuji, Nakagomi, Yasushi, Kobayashi, Fumiaki, Tanaka, Manabu, Doyu, Akira, Inukai, Mari, Yoshida, Yoshio, Hashizume, Gen, Sobue   +12 more
openaire   +2 more sources

An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy

BMC Cancer, 2006
Background Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in ...
Chen Liyong, Zhang Yan, Zhang Dong, Song Santai, Song Yuhua, Qian Lu, Shi Ming, Zhao Huibin, Jiang Zefei, Guo Ning   +9 more
doaj   +1 more source

Mast cell clones: a model for the analysis of cellular maturation. [PDF]

, 1982
Cloned mouse mast cells resemble, by ultrastructure, immature mast cells observed in vivo. These mast cell clones can be grown in the absence of any other cells, facilitating direct investigations of their biochemistry and function.
Cantor, H, Der Simonian, H, Dvorak, AM, Dvorak, HF, Galli, SJ, Goldin, JM, Ishizaka, T, Marcum, JA, Nabel, G, Pyne, K, Rosenberg, RD   +10 more
core   +2 more sources

Growth Factors, and Cytokines; Understanding the Role of Tyrosine Phosphatase SHP2 in Gametogenesis and Early Embryo Development

Cells, 2020
Growth factors and cytokines have vital roles in germ cell development, gamete maturation, and early embryo development. Cell surface receptors are present for growth factors and cytokines to integrate with and trigger protein signaling in the germ and ...
Muhammad Idrees, Seon-Hwa Oh, Tahir Muhammad, Marwa El-Sheikh, Seok-Hwan Song, Kyeong-Lim Lee, Il-Keun Kong   +6 more
doaj   +1 more source

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]

, 2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R., Benvenuto, M, Bonanno, E, Cucchi, Danilo, DE SMAELE, Enrico, DI STEFANO, Enrica, Fantini, M, Frajese, Gv, Gulino, Alberto, Masuelli, Laura, Mattera, Rosanna, Modesti, A, Orlandi, A, Screpanti, Isabella   +13 more
core   +1 more source

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets [PDF]

Diabetes & Metabolism Journal, 2019
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in
Jessica M. Ferrell, John Y. L. Chiang
doaj   +1 more source

γδ T cells affect IL-4 production and B-cell tolerance [PDF]

, 2014
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun, Cohen, Finkelman, Gerber, Greg A. Kirchenbaum, Hidaka, Hirose, Hua Huang, Izui, John C. Cambier, Koichi Ikuta, Kubo, Lawrence J. Wysocki, M. Kemal Aydintug, Rebecca L. O’Brien, Ryan A. Heiser, Simon R. Carding, Sperling, Sunaga, Tamara L. Casper, Thiago O. Detanico, Willi K. Born, Yafei Huang   +22 more
core   +1 more source

Importance of RIP140 and LCoR Sub-Cellular Localization for Their Association With Breast Cancer Aggressiveness and Patient Survival

Translational Oncology, 2018
New markers are needed to improve diagnosis and to personalize treatments for patients with breast cancer (BC). Receptor-interacting protein of 140 kDa (RIP140) and ligand-dependent corepressor (LCoR), two transcriptional co-regulators of estrogen ...
Sophie Sixou, Katharina Müller, Stéphan Jalaguier, Christina Kuhn, Nadia Harbeck, Doris Mayr, Jutta Engel, Udo Jeschke, Nina Ditsch, Vincent Cavaillès   +9 more
doaj   +1 more source

Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
The constitutive androstane receptor (CAR) is a ligand/activator-dependent transactivation factor that resides in the cytoplasm and forms part of an as yet unidentified protein complex. Upon stimulation, CAR translocates into the nucleus where it modulates the transactivation of target genes.
Kanno, Yuichiro, Suzuki, Motoyoshi, Nakahama, Takayuki, Inouye, Yoshio   +3 more
openaire   +2 more sources