Results 41 to 50 of about 285,475 (309)

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

Estrogen-mediated cytoplasmic and nuclear distribution of rat cardiovascular estrogen receptors. [PDF]

Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
We used either the synthetic estrogen R2858 (moxestrol) or estradiol-17 beta to characterize estrogen receptors in cytoplasmic (R2858) and nuclear (estradiol-17 beta) preparations from rat aorta and myocardium. Relative steroid specificity studies showed that only estrogens were effective inhibitors of R2858 or estradiol-17 beta binding to aortic and ...
A L, Lin, S A, Shain
openaire   +2 more sources

Specific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner. [PDF]

PLoS ONE, 2012
BACKGROUND: Nuclear myosin I (NM1) was the first molecular motor identified in the cell nucleus. Together with nuclear actin, they participate in crucial nuclear events such as transcription, chromatin movements, and chromatin remodeling.
Rastislav Dzijak, Sukriye Yildirim, Michal Kahle, Petr Novák, Jarmila Hnilicová, Tomáš Venit, Pavel Hozák   +6 more
doaj   +1 more source

The nuclear-cytoplasmic trafficking of a chromatin-modifyng and remodelling protein (KMT2C), in osteosarcoma [PDF]

, 2018
Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases.
Carletti, Raffaella, Chiappetta, Caterina, Della Rocca, Carlo, Di Cristofano, Claudio, Petrozza, Vincenzo, Puggioni, Chiara   +5 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Bile acids differentially regulate longitudinal smooth muscle contractility in everted mouse ileum

FASEB BioAdvances
Bile acids regulate gastrointestinal motility by mechanisms that are poorly understood. Standard isolated tissue bath assays might not recapitulate in vivo physiology if contractile responses to certain bile acids require direct application to the ...
Peace N. Dike, Krishnakant G. Soni, Diana S. Chang, Geoffrey A. Preidis   +3 more
doaj   +1 more source

Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis

Frontiers in Neuroscience
Cytoplasmic mislocalisation and nuclear depletion of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis (ALS), including mutations in the C9ORF72 gene that characterise the most common genetic form of ALS (C9ALS).
Manpreet Singh Atwal, Jerneja Nimac, Jerneja Nimac, Urša Čerček, Urša Čerček, Sarah Ricarda Goesch, Hannah Rebecca Goesch, Paraskevi Tziortzouda, Tiziana Ercolani, Anna Zatorska, Terouz Pasha, Ivo Carre, Jacqueline Mitchell, Claire Troakes, Bart Tummers, Vera Župunski, Boris Rogelj, Boris Rogelj, Tibor Hortobágyi, Tibor Hortobágyi, Frank Hirth   +20 more
doaj   +1 more source

Androgen Receptors Expression in Pituitary of Male Viscacha in relation to Growth and Reproductive Cycle

International Journal of Endocrinology, 2015
The aim of this work was to study the androgen receptors (AR) expression in pituitary pars distalis (PD) of male viscachas in relation to growth and reproductive cycle. AR were detected by immunocytochemistry and quantified by image analysis.
Verónica Palmira Filippa, Gabriela Judith Rosales, Albana Andrea Marina Cruceño, Fabian Heber Mohamed   +3 more
doaj   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source