Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger [PDF]
, 2016 In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits ...
Akira +152 more
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Cytoplasmic and Nuclear Estradiol Receptor in the Corpus Luteum of the Pseudopregnant Rabbit
Experimental Biology and Medicine, 1979 SummaryEstradiol binding activity has been measured in the rabbit corpus luteum on Days 2, 4, and 6 of pseudopregnancy. The results show that receptor activity is significantly greater on Day 4 than on Day 2 with continued increases on Day 6. In addition, the estradiol receptor activity is translocated into the nucleus within 30 min of injection of 100
openaire +3 more sources
Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor. [PDF]
, 1993 The 17-juxtamembrane cytoplasmic residues of the polymeric immunoglobulin receptor contain an autonomous basolateral targeting signal that does not mediate rapid endocytosis (Casanova, J. E., G. Apodaca, and K. E. Mostov. Cell. 66:65-75).
Aroeti, B +4 more
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Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures [PDF]
, 2015 Background: In the last years, Wnt signaling was demonstrated to regulate inflammatory processes. In particular, an increased expression of Wnts and Frizzled receptors was reported in inflammatory bowel disease (IBD) and ulcerative colitis to exert both ...
Anne, Schuster +7 more
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Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus [PDF]
, 2004 The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established.
Galigniana, Mario Daniel +4 more
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Identification of the zinc finger 216 (ZNF216) in human carcinoma cells. A potential regulator of EGFR activity [PDF]
, 2016 Epidermal Growth Factor Receptor (EGFR), a member of the ErbB family of receptor tyrosine kinase (RTK) proteins, is aberrantly expressed or deregulated in tumors and plays pivotal roles in cancer onset and metastatic progression.
Calogero, Antonella +10 more
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LRR-containing receptors regulating plant development and defense [PDF]
, 2004 Despite the presence of more than 400 genes that encode receptor-like kinases (RLKs) in the Arabidopsis thaliana genome, very little is known about the range of biological processes that they control, or the mechanisms by which they function. This review
Clark, Steven E., Dievart, Anne
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Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]
, 2011 Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Arash Y. Tehrani +5 more
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HTR4 gene structure and altered expression in the developing lung [PDF]
, 2013 Background: Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT4R) gene (HTR4) associated with lung function.
Billington, CK +11 more
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Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]
, 2016 Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja +2 more
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