Results 81 to 90 of about 299,088 (322)

Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors

Journal of Biological Chemistry, 2001
In this report, we have studied the intracellular dynamics and distribution of the thyroid hormone receptor-β (TRβ) in living cells, utilizing fusions to the green fluorescent protein.
C. Baumann, Padma Maruvada, G. Hager, P. Yen   +3 more
semanticscholar   +1 more source

A Study of Cytoplasmic and Nuclear Estrogen and Progestin Receptors in Gynecologic Neoplasms

Endocrinologia Japonica, 1987
A rapid method for simultaneous preparation of cytosol and nuclear estrogen (E) and progestin (P) receptors and their in vitro determination is described. The method was applied to several uterine or ovarian surgical specimens to evaluate their steroid hormone "dependence". The results suggest that low cytoplasmic E receptor levels (ERc) are associated
H, Sakamoto, N J, Maclusky, P E, Schwartz, F, Naftolin, D, Phil, K, Den, S, Takagi   +6 more
openaire   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

All Hands on Deck—The Role of Chloroplasts, Endoplasmic Reticulum, and the Nucleus in Driving Plant Innate Immunity

Molecular Plant-Microbe Interactions, 2010
Plant innate immunity is mediated by cell membrane and intracellular immune receptors that function in distinct and overlapping cell-signaling pathways to activate defense responses.
Meenu S. Padmanabhan, S. P. Dinesh-Kumar
doaj   +1 more source

Limited Proteolysis of Cytoplasmic and Nuclear Uterine Estradiol Receptors Yields Identical Estradiol‐Binding Fragments [PDF]

European Journal of Biochemistry, 1976
Limited tryptic hydrolysis of the estradiol cytoplasmic receptor from calf uterus has been demonstrated to yield in a high‐salt buffer a stable estradiol‐binding molecule with the following characteristics: sedimentation coefficient 4,0 ± 0.1 S; Stokes radius 3.5 ± 0.05 nm; molecular weight 60000 (for an assumed v̄ value of 0.73 ml g−1) and frictional ...
C, Vallet-Strouve, L, Rat, J M, Sala-Trepat   +2 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Cytoplasmic Localization of Pregnane X Receptor and Ligand-dependent Nuclear Translocation in Mouse Liver [PDF]

Journal of Biological Chemistry, 2004
The pregnane X receptor (PXR) plays an important role in the response to xenobiotics and endogenous toxins. We have used a specific anti-PXR antibody in the Western blotting of mouse liver nuclear extracts to show that PXR is accumulated in the nucleus after treatment with 5-pregnen-3beta-ol-20-one-16alpha-carbonitrile (PCN), followed by an increase in
E James, Squires, Tatsuya, Sueyoshi, Masahiko, Negishi   +2 more
openaire   +2 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]

, 1995
To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel, Fiala, John C., Grossberg, Stephen   +2 more
core   +1 more source

Primordial follicular assembly in humans : revisited [PDF]

, 2009
Peer ...
A. Maheshwari, Baker, Donovan, Gumienny, Konishi, P. A. Fowler, Pinkerton, Satoh, Vaskivuo   +8 more
core   +1 more source