Results 101 to 110 of about 288,899 (312)

Structural and biochemical studies of an NB-ARC domain from a plant NLR immune receptor.

PLoS ONE, 2019
Plant NLRs are modular immune receptors that trigger rapid cell death in response to attempted infection by pathogens. A highly conserved nucleotide-binding domain shared with APAF-1, various R-proteins and CED-4 (NB-ARC domain) is proposed to act as a ...
John F C Steele, Richard K Hughes, Mark J Banfield   +2 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

The intracellular domain of the low affinity p75 nerve growth factor receptor is a death effector domain

Molecular Medicine Reports, 2009
The death domain superfamily, comprising the death domain, death effector domain, caspase recruitment domain and pyrin domain subfamilies, is one of the largest classes of protein interaction modules, and plays a particularly critical function in the assembly and activation of apoptotic and inflammatory complexes.
openaire   +3 more sources

The Cyst Nematode SPRYSEC Protein RBP-1 Elicits Gpa2- and RanGAP2-Dependent Plant Cell Death

, 2009
Plant NB-LRR proteins confer robust protection against microbes and metazoan parasites by recognizing pathogen-derived avirulence (Avr) proteins that are delivered to the host cytoplasm.
Moffett, Peter, Alexandra Blanchard, Goverse Aska, Smant, G., Sacco, Melanie Ann, Koropacka, Kamila, Smant Geert, Peter Moffett, Grenier, E., Jaubert, Marianne J., Grenier, Eric, Goverse, A., Blanchard, A., Kamila Koropacka, Melanie Ann Sacco, Aska Goverse, Goverse, Aska, Moffett, P., Smant, Geert, Geert Smant, Koropacka, K.B., Blanchard, Alexandra, Moffett Peter, Jaubert Marianne J., Koropacka Kamila, Eric Grenier, Sacco, M.A., Sacco Melanie Ann, Marianne J Jaubert, Jaubert, M.J., Grenier Eric, Blanchard Alexandra   +31 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The IRAK-M death domain: a tale of three surfaces

Frontiers in Molecular Biosciences
The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 dependent ...
Berke Gürkan, Berke Gürkan, Hessel Poelman, Hessel Poelman, Liza Pereverzeva, Liza Pereverzeva, Danielle Kruijswijk, Danielle Kruijswijk, Alex F. de Vos, Alex F. de Vos, Anouk G. Groenen, Anouk G. Groenen, Edgar E. Nollet, Edgar E. Nollet, Kanin Wichapong, Esther Lutgens, Tom van der Poll, Tom van der Poll, Tom van der Poll, Jiangfeng Du, W. Joost Wiersinga, W. Joost Wiersinga, W. Joost Wiersinga, Gerry A. F. Nicolaes, Gerry A. F. Nicolaes, Cornelis van ‘t Veer, Cornelis van ‘t Veer   +26 more
doaj   +1 more source

Molecular pharmacology of AMPA receptor trafficking proteins - TARPs - evidence for an association with 5HT(_2c) receptors [PDF]

, 2009
There has been an increasing awareness of the involvement of neurotransmitters other than serotonin in depression, with new antidepressants possessing effects on other receptor types, such as Agomelatine®, an antagonist of 5HT(_2c) receptors that ...
Donoghue, Peter, Donoghue , Peter
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor

BMC Neuroscience, 2004
Background Lithium, a mood stabilizer widely used to treat bipolar disorder, also is a neuroprotectant, providing neurons protection from apoptosis induced by a broad spectrum of toxic conditions.
Jope Richard S, Zhou Tong, Song Ling
doaj   +1 more source

Purinergic receptors in skeletal muscles in health and in muscular dystrophy

, 2014
The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways.
Young, Christopher, Zablocki, Krzysztof, Rog, Justyna, Young, Christopher N. J., Rog, J., Gorecki, Dariusz, Zablocki, K., Krasowska, Elzbieta, Sinadinos, Anthony, Gorecki, Darek, Krasowska, E.   +10 more
core   +1 more source