Results 31 to 40 of about 287,209 (264)

Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling [PDF]

Journal of Biological Chemistry, 2008
The Drosophila Toll receptor is activated by the endogenous protein ligand Spätzle in response to microbial stimuli in immunity and spatial cues during embryonic development. Downstream signaling is mediated by the adaptor proteins Tube, the kinase Pelle, and the Drosophila homologue of myeloid differentiation primary response protein (dMyD88). Here we
Martin C, Moncrieffe, J Günter, Grossmann, Nicholas J, Gay   +2 more
openaire   +2 more sources

The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity. [PDF]

PLoS ONE, 2012
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) ligand family that exerts its apoptotic activity in human cells by binding to two transmembrane receptors, TRAILR1 and TRAILR2.
Simon Neumann, Tobias Bidon, Marcus Branschädel, Anja Krippner-Heidenreich, Peter Scheurich, Malgorzata Doszczak   +5 more
doaj   +1 more source

N-terminal and C-terminal domains of calmodulin mediate FADD and TRADD interaction.

PLoS ONE, 2015
FADD (Fas-associated death domain) and TRADD (Tumor Necrosis Factor Receptor 1-associated death domain) proteins are important regulators of cell fate in mammalian cells. They are both involved in death receptors mediated signaling pathways and have been
Giuliana Papoff, Nadia Trivieri, Sonia Marsilio, Roberta Crielesi, Cristiana Lalli, Loriana Castellani, Edward M Balog, Giovina Ruberti   +7 more
doaj   +1 more source

The Features of Checkpoint Receptor—Ligand Interaction in Cancer and the Therapeutic Effectiveness of Their Inhibition

Biomedicines, 2022
To date, certain problems have been identified in cancer immunotherapy using the inhibition of immune checkpoints (ICs). Despite the excellent effect of cancer therapy in some cases when blocking the PD-L1 (programmed death-ligand 1) ligand and the ...
Anna Kuzevanova, Natalya Apanovich, Danzan Mansorunov, Alexandra Korotaeva, Alexander Karpukhin   +4 more
doaj   +1 more source

A Prosurvival Function for the p75 Receptor Death Domain Mediated via the Caspase Recruitment Domain Receptor-Interacting Protein 2 [PDF]

The Journal of Neuroscience, 2001
In addition to promoting cell survival, neurotrophins also can elicit apoptosis in restricted cell types. Recent results indicate that nerve growth factor (NGF) can induce Schwann cell death via engagement of the p75 neurotrophin receptor. Here we describe a novel interaction between the p75 receptor and receptor-interacting protein 2, RIP2 (RICK ...
G, Khursigara, J, Bertin, H, Yano, H, Moffett, P S, DiStefano, M V, Chao   +5 more
openaire   +2 more sources

The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution

BMC Evolutionary Biology, 2008
Background Recent studies have revealed an unexpected diversity of domain architecture among FcR-like receptors that presumably fulfill regulatory functions in the immune system.
Najakshin Alexander M, Mechetina Ludmila V, Erilova Aleksandra Y, Ramanayake Thaminda, Guselnikov Sergey V, Robert Jacques, Taranin Alexander V   +6 more
doaj   +1 more source

Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis [PDF]

Current Biology, 1999
Normal epithelial cells undergo apoptosis if integrinmediated matrix contacts are lost, in a process termed 'anoikis'. Anoikis prevents shed epithelial cells from colonizing elsewhere, and is thus essential for maintaining appropriate tissue organisation. Aberrant oncogenes or tumor suppressor genes can cause resistance to anoikis, thereby contributing
openaire   +2 more sources

ER-mediated control for abundance, quality, and signaling of transmembrane immune receptors in plants

Frontiers in Plant Science, 2014
Plants recognize a wide range of microbes with cell-surface and intracellular immune receptors. Transmembrane pattern recognition receptors (PRRs) initiate immune responses upon recognition of cognate ligands characteristic of microbes or aberrant ...
Nico eTintor, Yusuke eSaijo
doaj   +1 more source

The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4.

PLoS Genetics, 2022
Cell surface pattern recognition receptors (PRRs) activate immune responses that can include the hypersensitive cell death. However, the pathways that link PRRs to the cell death response are poorly understood.
Jiorgos Kourelis, Mauricio P Contreras, Adeline Harant, Hsuan Pai, Daniel Lüdke, Hiroaki Adachi, Lida Derevnina, Chih-Hang Wu, Sophien Kamoun   +8 more
doaj   +1 more source

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

Cell Reports, 2019
Summary: VPS10P domain receptors emerge as central regulators of intracellular protein sorting in neurons with relevance for various brain pathologies. Here, we identified a role for the family member SorCS2 in protection of neurons from oxidative stress
Anna R. Malik, Kinga Szydlowska, Karolina Nizinska, Antonino Asaro, Erwin A. van Vliet, Oliver Popp, Gunnar Dittmar, Raphaela Fritsche-Guenther, Jennifer A. Kirwan, Anders Nykjaer, Katarzyna Lukasiuk, Eleonora Aronica, Thomas E. Willnow   +12 more
doaj   +1 more source