Results 41 to 50 of about 287,209 (264)

Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor [PDF]

FEBS Letters, 1998
Tumor nectosis factor (TNF) receptors are key players in inflammation and immune regulation. A new member of this family, termed death receptor‐6 (DR6), has been identified. Like other death receptors, DR6 is a type I transmembrane receptor, possesses four extracellular cysteine‐rich motifs and a cytoplasmic death domain. DR6 is expressed in most human
Pan, Guohua, Bauer, Johannes H, Haridas, Valsala, Wang, Shuxia, Liu, Ding, Yu, Guoliang, Vincenz, Claudius, Aggarwal, Bharat B, Ni, Jian, Dixit, Vishva M   +9 more
openaire   +3 more sources

Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia

Neurobiology of Disease, 2016
Global cerebral ischemia induces selective degeneration of specific subsets of neurons throughout the brain, particularly in the hippocampus and cortex. One of the major hallmarks of cerebral ischemia is excitotoxicity, characterized by overactivation of
Marta M. Vieira, Jeannette Schmidt, Joana S. Ferreira, Kevin She, Shinichiro Oku, Miranda Mele, Armanda E. Santos, Carlos B. Duarte, Ann Marie Craig, Ana Luísa Carvalho   +9 more
doaj   +1 more source

The Fas–FADD death domain complex structure unravels signalling by receptor clustering [PDF]

Nature, 2008
The death inducing signalling complex (DISC) formed by Fas receptor, FADD (Fas-associated death domain protein) and caspase 8 is a pivotal trigger of apoptosis. The Fas-FADD DISC represents a receptor platform, which once assembled initiates the induction of programmed cell death.
Scott, Fiona L., Stec, Boguslaw, Pop, Cristina, Dobaczewska, Małgorzata K., Lee, JeongEun J., Monosov, Edward, Robinson, Howard, Salvesen, Guy S., Schwarzenbacher, Robert, Riedl, Stefan J.   +9 more
openaire   +2 more sources

Structural basis of death domain signaling in the p75 neurotrophin receptor

eLife, 2015
Death domains (DDs) mediate assembly of oligomeric complexes for activation of downstream signaling pathways through incompletely understood mechanisms. Here we report structures of complexes formed by the DD of p75 neurotrophin receptor (p75NTR) with RhoGDI, for activation of the RhoA pathway, with caspase recruitment domain (CARD) of RIP2 kinase, for
Zhi Lin, Jason Y Tann, Eddy TH Goh, Claire Kelly, Kim Buay Lim, Jian Fang Gao, Carlos F Ibanez   +6 more
openaire   +3 more sources

The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections

Frontiers in Immunology, 2018
Costimulatory and coinhibitory receptors play a key role in regulating immune responses to infection and cancer. Coinhibitory receptors include programmed cell death 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and T cell ...
Keiko Yasuma-Mitobe, Masao Matsuoka, Masao Matsuoka   +2 more
doaj   +1 more source

Rice XB15, a protein phosphatase 2C, negatively regulates cell death and XA21-mediated innate immunity. [PDF]

PLoS Biology, 2008
Perception of extracellular signals by cell surface receptors is of central importance to eukaryotic development and immunity. Kinases that are associated with the receptors or are part of the receptors themselves modulate signaling through ...
Chang-Jin Park, Ying Peng, Xuewei Chen, Christopher Dardick, Deling Ruan, Rebecca Bart, Patrick E Canlas, Pamela C Ronald   +7 more
doaj   +1 more source

Expression of Silencer of Death Domains and Death-Receptor-3 in Normal Human Kidney and in Rejecting Renal Transplants [PDF]

The American Journal of Pathology, 2003
We have previously reported the pattern of cellular expression of tumor necrosis factor receptors (TNFR) in human kidney and their altered expression in transplant rejection. We have extended our studies to examine the expression of Silencer of Death Domains (SODD), a protein that binds to the cytoplasmic portion of TNFR1 to inhibit signaling in the ...
Rafia S, Al-Lamki, Jun, Wang, Sathia, Thiru, Nicholas R, Pritchard, J Andrew, Bradley, Jordan S, Pober, John R, Bradley   +6 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish

BMC Genomics, 2007
Background Death receptors on the cell surface and the interacting cytosolic molecules, adaptors and initiator caspases, are essential as core components of the extrinsic apoptotic signaling pathway.
Kominami Katsuya, Nozaki Masami, Sakamaki Kazuhiro, Satou Yutaka   +3 more
doaj   +1 more source

Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS [PDF]

The Journal of Neuroscience, 2016
The p75 neurotrophin receptor (p75 NTR ) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway. The oligomeric state and activation mechanism that enable p75 NTR to mediate these effects have recently been ...
Kazuhiro Tanaka, Claire E. Kelly, Ket Yin Goh, Kim Buay Lim, Carlos F. Ibáñez   +4 more
openaire   +3 more sources