Results 61 to 70 of about 4,743,951 (299)

Structural Dynamics and Allosteric Signaling in Ionotropic Glutamate Receptors [PDF]

, 2013
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission events in the central nervous system. All distinct classes of iGluRs (AMPA, NMDA, Kainate) are composed of an N-terminal domain (NTD) and a ...
Dutta, Anindita
core  

Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment

Cells, 2022
Signaling through the TNF-family receptor Fas/CD95 can trigger apoptosis or non-apoptotic cellular responses and is essential for protection from autoimmunity.
Nicholas Frazzette, Anthony C. Cruz, Xufeng Wu, John A. Hammer, Jennifer Lippincott-Schwartz, Richard M. Siegel, Prabuddha Sengupta   +6 more
doaj   +1 more source

A Prosurvival Function for the p75 Receptor Death Domain Mediated via the Caspase Recruitment Domain Receptor-Interacting Protein 2 [PDF]

The Journal of Neuroscience, 2001
In addition to promoting cell survival, neurotrophins also can elicit apoptosis in restricted cell types. Recent results indicate that nerve growth factor (NGF) can induce Schwann cell death via engagement of the p75 neurotrophin receptor. Here we describe a novel interaction between the p75 receptor and receptor-interacting protein 2, RIP2 (RICK ...
G, Khursigara, J, Bertin, H, Yano, H, Moffett, P S, DiStefano, M V, Chao   +5 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Role of Immunomodulatory Receptors in the Pathogenesis of HIV Infection: A Therapeutic Opportunity for HIV Cure?

Frontiers in Immunology, 2020
Immune activation is the hallmark of HIV infection and plays a role in the pathogenesis of the disease. In the context of suppressed HIV RNA replication by combination antiretroviral therapy (cART), there remains immune activation which is associated to ...
Hui Chen, Hui Chen, Maha Moussa, Marta Catalfamo   +3 more
doaj   +1 more source

Structural basis of death domain signaling in the p75 neurotrophin receptor

eLife, 2015
Death domains (DDs) mediate assembly of oligomeric complexes for activation of downstream signaling pathways through incompletely understood mechanisms. Here we report structures of complexes formed by the DD of p75 neurotrophin receptor (p75NTR) with RhoGDI, for activation of the RhoA pathway, with caspase recruitment domain (CARD) of RIP2 kinase, for
Zhi Lin, Jason Y Tann, Eddy TH Goh, Claire Kelly, Kim Buay Lim, Jian Fang Gao, Carlos F Ibanez   +6 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides [PDF]

, 2009
Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E., Cherie E Bond, Greenfield Susan A., Susan A Greenfield, Greenfield, SA, Martina Zimmermann, Zimmermann, M, Bond Cherie E., Greenfield, Susan A, Bond, CE, Zimmermann Martina, Greenfield, Susan A., Bond, Cherie E, Zimmermann, Martina, Greenfield, Susan   +14 more
core   +2 more sources

Targeting Innate Immunity in Cancer Therapy

Vaccines, 2021
The majority of current cancer immunotherapy strategies target and potentiate antitumor adaptive immune responses. Unfortunately, the efficacy of these treatments has been limited to a fraction of patients within a subset of tumor types, with an ...
Srikrishnan Rameshbabu, Brian W. Labadie, Anna Argulian, Akash Patnaik   +3 more
doaj   +1 more source