Results 41 to 50 of about 4,743,951 (299)
Neurobiology of Disease, 2016 Global cerebral ischemia induces selective degeneration of specific subsets of neurons throughout the brain, particularly in the hippocampus and cortex. One of the major hallmarks of cerebral ischemia is excitotoxicity, characterized by overactivation of
Marta M. Vieira +9 more
doaj +1 more source
Identification of the Calmodulin-Binding Domains of Fas Death Receptor
PLOS ONE, 2016 The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor Fas protein. Subsequently, the intracellular death domain of Fas (FasDD) and that of the Fas-associated protein (FADD) interact to form the core of the death-inducing signaling complex (DISC), a crucial step for activation of caspases
Bliss J Chang +6 more
openaire +4 more sources
The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections
Frontiers in Immunology, 2018 Costimulatory and coinhibitory receptors play a key role in regulating immune responses to infection and cancer. Coinhibitory receptors include programmed cell death 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and T cell ...
Keiko Yasuma-Mitobe +2 more
doaj +1 more source
Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis [PDF]
Current Biology, 1999 Normal epithelial cells undergo apoptosis if integrinmediated matrix contacts are lost, in a process termed 'anoikis'. Anoikis prevents shed epithelial cells from colonizing elsewhere, and is thus essential for maintaining appropriate tissue organisation. Aberrant oncogenes or tumor suppressor genes can cause resistance to anoikis, thereby contributing
openaire +2 more sources
Rice XB15, a protein phosphatase 2C, negatively regulates cell death and XA21-mediated innate immunity. [PDF]
PLoS Biology, 2008 Perception of extracellular signals by cell surface receptors is of central importance to eukaryotic development and immunity. Kinases that are associated with the receptors or are part of the receptors themselves modulate signaling through ...
Chang-Jin Park +7 more
doaj +1 more source
Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling [PDF]
Journal of Biological Chemistry, 2008 The Drosophila Toll receptor is activated by the endogenous protein ligand Spätzle in response to microbial stimuli in immunity and spatial cues during embryonic development. Downstream signaling is mediated by the adaptor proteins Tube, the kinase Pelle, and the Drosophila homologue of myeloid differentiation primary response protein (dMyD88). Here we
Martin C, Moncrieffe +2 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens +6 more
wiley +1 more source
Structural and functional investigation of the cytoplasmic domain of the Fas death receptor [PDF]
, 2015 Activation of the transmembrane death receptor Fas (CD95/APO-1) by a membrane bound ligand (FasL/CD95L) activates the extrinsic pathway of apoptosis. Intracellular Fas death domains (DDs) are induced to oligomerise enabling binding to the adaptor protein
Wildsmith, GC
core
Ligand-binding domain determines endoplasmic reticulum exit of AMPA receptors.
, 2010 AMPA receptors (AMPARs) are tetrameric ion channels that mediate rapid glutamate signaling in neurons and many non-neuronal cell types. Endoplasmic reticulum (ER) quality control mechanisms permit only correctly folded functional receptors to be ...
Coleman, S.K. +6 more
core +1 more source
New Insights into VacA Intoxication Mediated through Its Cell Surface Receptors
Toxins, 2016 Helicobacter pylori (H. pylori), a major cause of gastroduodenal diseases, produces VacA, a vacuolating cytotoxin associated with gastric inflammation and ulceration.
Kinnosuke Yahiro +3 more
doaj +1 more source