Results 31 to 40 of about 4,743,951 (299)

Functional roles in cell signaling of adaptor protein TRADD from a structural perspective

Computational and Structural Biotechnology Journal, 2020
TRADD participates in various receptor signaling pathways and plays vital roles in many biological activities, including cell survival and apoptosis, in different cellular contexts.
Zhen Li, Wensu Yuan, Zhi Lin
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N-terminal and C-terminal domains of calmodulin mediate FADD and TRADD interaction.

PLoS ONE, 2015
FADD (Fas-associated death domain) and TRADD (Tumor Necrosis Factor Receptor 1-associated death domain) proteins are important regulators of cell fate in mammalian cells. They are both involved in death receptors mediated signaling pathways and have been
Giuliana Papoff, Nadia Trivieri, Sonia Marsilio, Roberta Crielesi, Cristiana Lalli, Loriana Castellani, Edward M Balog, Giovina Ruberti   +7 more
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The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity. [PDF]

PLoS ONE, 2012
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) ligand family that exerts its apoptotic activity in human cells by binding to two transmembrane receptors, TRAILR1 and TRAILR2.
Simon Neumann, Tobias Bidon, Marcus Branschädel, Anja Krippner-Heidenreich, Peter Scheurich, Malgorzata Doszczak   +5 more
doaj   +1 more source

The Features of Checkpoint Receptor—Ligand Interaction in Cancer and the Therapeutic Effectiveness of Their Inhibition

Biomedicines, 2022
To date, certain problems have been identified in cancer immunotherapy using the inhibition of immune checkpoints (ICs). Despite the excellent effect of cancer therapy in some cases when blocking the PD-L1 (programmed death-ligand 1) ligand and the ...
Anna Kuzevanova, Natalya Apanovich, Danzan Mansorunov, Alexandra Korotaeva, Alexander Karpukhin   +4 more
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A novel receptor for Apo2L/TRAIL contains a truncated death domain [PDF]

Current Biology, 1997
Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the TNF family and activates apoptosis in tumor cells. Three closely related receptors bind Apo2L: DR4 and DR5, which contain cytoplasmic death domains and signal apoptosis, and DcR1, a decoy receptor that lacks a cytoplasmic tail
Marsters, S.A., Sheridan, J.P., Pitti, R.M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A.D., Godowski, P., Ashkenazi, A.   +10 more
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The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution

BMC Evolutionary Biology, 2008
Background Recent studies have revealed an unexpected diversity of domain architecture among FcR-like receptors that presumably fulfill regulatory functions in the immune system.
Najakshin Alexander M, Mechetina Ludmila V, Erilova Aleksandra Y, Ramanayake Thaminda, Guselnikov Sergey V, Robert Jacques, Taranin Alexander V   +6 more
doaj   +1 more source

Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death [PDF]

Journal of Biological Chemistry, 2000
The cytoplasmic juxtamembrane region of the p75 neurotrophin receptor (p75(NTR)) has been found to be necessary and sufficient to initiate neural cell death. The region was named "Chopper" to distinguish it from CD95-like death domains. A 29-amino acid peptide corresponding to the Chopper region induced caspase- and calpain-mediated death in a variety ...
Coulson, E. J., Reid, K., Baca, M., Shipham, K. A., Hulett, S. M., Kilpatrick, T. J., Bartlett, P. F.   +6 more
openaire   +5 more sources

ER-mediated control for abundance, quality, and signaling of transmembrane immune receptors in plants

Frontiers in Plant Science, 2014
Plants recognize a wide range of microbes with cell-surface and intracellular immune receptors. Transmembrane pattern recognition receptors (PRRs) initiate immune responses upon recognition of cognate ligands characteristic of microbes or aberrant ...
Nico eTintor, Yusuke eSaijo
doaj   +1 more source

The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4.

PLoS Genetics, 2022
Cell surface pattern recognition receptors (PRRs) activate immune responses that can include the hypersensitive cell death. However, the pathways that link PRRs to the cell death response are poorly understood.
Jiorgos Kourelis, Mauricio P Contreras, Adeline Harant, Hsuan Pai, Daniel Lüdke, Hiroaki Adachi, Lida Derevnina, Chih-Hang Wu, Sophien Kamoun   +8 more
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SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

Cell Reports, 2019
Summary: VPS10P domain receptors emerge as central regulators of intracellular protein sorting in neurons with relevance for various brain pathologies. Here, we identified a role for the family member SorCS2 in protection of neurons from oxidative stress
Anna R. Malik, Kinga Szydlowska, Karolina Nizinska, Antonino Asaro, Erwin A. van Vliet, Oliver Popp, Gunnar Dittmar, Raphaela Fritsche-Guenther, Jennifer A. Kirwan, Anders Nykjaer, Katarzyna Lukasiuk, Eleonora Aronica, Thomas E. Willnow   +12 more
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