Results 21 to 30 of about 4,743,951 (299)

Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System

Frontiers in Genetics, 2020
Rationally engineered improvements to crop plants will be needed to keep pace with increasing demands placed on agricultural systems by population growth and climate change.
Adam M. Bayless, Marc T. Nishimura
doaj   +1 more source

Role of ADGRG1/GPR56 in Tumor Progression

Cells, 2021
Cellular communication plays a critical role in diverse aspects of tumorigenesis including tumor cell growth/death, adhesion/detachment, migration/invasion, angiogenesis, and metastasis.
Kwai-Fong Ng, Tse-Ching Chen, Martin Stacey, Hsi-Hsien Lin   +3 more
doaj   +1 more source

Arg-GlcNAcylation on TRADD by NleB and SseK1 Is Crucial for Bacterial Pathogenesis

Frontiers in Cell and Developmental Biology, 2020
Death receptor signaling is critical for cell death, inflammation, and immune homeostasis. Hijacking death receptors and their corresponding adaptors through type III secretion system (T3SS) effectors has been evolved to be a bacterial evasion strategy ...
Juan Xue, Juan Xue, Juan Xue, Shufan Hu, Shufan Hu, Yuxuan Huang, Yuxuan Huang, Qi Zhang, Qi Zhang, Xueying Yi, Xueying Yi, Xing Pan, Xing Pan, Xing Pan, Shan Li, Shan Li, Shan Li   +16 more
doaj   +1 more source

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells

Frontiers in Cell and Developmental Biology, 2022
Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well ...
Anna-Christina Rambow, Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Jan-Paul Gundlach, Sebastian Weiße, Nicolai Maass, Anna Trauzold, Anna Trauzold   +10 more
doaj   +1 more source

Identification of a ligand for the death-domain-containing receptor Apo3 [PDF]

Current Biology, 1998
The tumor necrosis factor (TNF) cytokine family regulates development and function of the immune system [1]. TNF is expressed primarily by activated lymphocytes and macrophages and induces gene transcription or apoptosis in target cells [2,3]. We have identified a novel relative of TNF that binds to the recently discovered, death-domain-containing ...
Marsters, Scot A., Sheridan, James P., Pitti, Robert M., Brush, Jennifer, Goddard, Audrey, Ashkenazi, Avi   +5 more
openaire   +2 more sources

Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. [PDF]

, 2009
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species.
Gerhard Rammes, Caroline Nothdurfter, Tanasic, S., Rammes, G., Rupprecht, R., Eisensamer, Brigitte, Zieglgänsberger Walter, Christine Hosp, Tanasic, Sascha, Hosp Christine, Walter Zieglgänsberger, Rupprecht Rainer, Rammes, Gerhard, Sascha Tanasic, Hosp, C., Rammes Gerhard, Nothdurfter, C., Tanasic Sascha, Rupprecht, Rainer, Nothdurfter Caroline, Brigitte Eisensamer, Eisensamer, B., Zieglgänsberger, Walter, Zieglgänsberger, W., Hosp, Christine, Rainer Rupprecht, Nothdurfter, Caroline, Eisensamer Brigitte   +27 more
core   +2 more sources

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines [PDF]

, 2009
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5).
M Keane, Mehmet, H, A Samali, D Mahalingam, H Mehmet, Mahalingam, D, E Szegezdi, Szegezdi, E, Keane, M, G Pirianov, Pirianov, G, Samali, A   +11 more
core   +1 more source

Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. [PDF]

PLoS ONE, 2012
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can antagonize Wnt/β-catenin signaling, including the decoy receptors known as secreted frizzled related proteins (SFRPs), which ...
Ismaïl Hendaoui, Elise Lavergne, Heun-Sik Lee, Seong Hyun Hong, Hak-Zoo Kim, Christelle Parent, Nathalie Heuzé-Vourc'h, Bruno Clément, Orlando Musso   +8 more
doaj   +1 more source

PD-L1 is expressed on human activated naive effector CD4+ T cells. Regulation by dendritic cells and regulatory CD4+ T cells.

PLoS ONE, 2021
The T cell expression of various co-signalling receptors from the CD28 immunoglobulin superfamily (Inducible T cell co-stimulator (ICOS), Programmed cell death 1(PD-1), cytotoxic T lymphocyte associated protein 4 (CTLA-4), B and T lymphocyte attenuator ...
Fabienne Mazerolles, Frédéric Rieux-Laucat   +1 more
doaj   +2 more sources

Structure of TRAF Family: Current Understanding of Receptor Recognition

Frontiers in Immunology, 2018
Tumor necrosis factor receptor–associated factor (TRAF) proteins are key signaling molecules that function in various cellular signaling events including immune response, cell death and survival, development, and thrombosis.
Hyun H. Park
doaj   +1 more source