Results 211 to 220 of about 294,900 (263)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

c-FLIP as a master regulator of immune homeostasis and disease mechanisms. [PDF]

Cell Death Dis
Urbini E, Adamo A, Hu Y, Giacobazzi L, Dusi S, De Sanctis F, Carbone C, Gibellini D, Pilotto S, Corbo V, Bronte V, Vascotto F, Ugel S.   +12 more
europepmc   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular-Immune Crosstalk in Dengue. [PDF]

FASEB J
da Silva-Alencar ABA, Matos AO, de Sousa DF, Dietz JDC, Hottz ED, da Silva-Sales MFM, Sales-Campos H.   +6 more
europepmc   +1 more source

Different Immune Cells Modified With Chimeric Antigen Receptors Are Being Applied to Ovarian Cancer: Which Is the Most Effective? [PDF]

Cancer Med
Wang L, Cao Y, Ren Y, Zhang Y, Wang L.
europepmc   +1 more source

Engineering plant tandem kinase immune receptors expands effector recognition profiles

Yu DS, Zdrzałek R, Katayama E, Akiyama H, Daykin L, Williams NJ, Goodridge I, Asuke S, Banfield MJ.   +8 more
europepmc   +1 more source

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Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors

Biochemical and Biophysical Research Communications, 2005
Death receptors (DRs) can induce apoptosis by oligomerization with TRAIL, whereas death decoy receptors (DcRs) cannot, due to their lack of functional intracellular death domains. However, it is not known whether DRs and DcRs can interact with one another to form oligomeric complexes prior to TRAIL binding.
Hyun-Wook, Lee, Seung-Hyun, Lee, Hae-Won, Lee, Yeon-Woo, Ryu, Myung-Hee, Kwon, Yong-Sung, Kim   +5 more
openaire   +2 more sources

Apoptotic and necrotic cell death induced by death domain receptors

Cellular and Molecular Life Sciences, 2001
Apoptosis and necrosis are two distinct forms of cell death. Caspases are indispensable as initiators and effectors of apoptotic cell death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the ...
G, Denecker, D, Vercammen, W, Declercq, P, Vandenabeele   +3 more
openaire   +2 more sources