Results 221 to 230 of about 294,900 (263)

A death-domain-containing receptor that mediates apoptosis

Nature, 1996
The cell-killing effects of the cytokines TNF-alpha and FasL are mediated by the distinct cell-surface receptors TNFR1, TNFR2 and Fas (also known as CD95/APO-1), which are all members of a receptor superfamily that is important for regulating cell survival.
J, Kitson, T, Raven, Y P, Jiang, D V, Goeddel, K M, Giles, K T, Pun, C J, Grinham, R, Brown, S N, Farrow   +8 more
openaire   +2 more sources

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

Science, 1997
TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain–containing receptor, DR4, is expressed on both cell types. An antagonist decoy receptor (designated as TRID for TRAIL receptor without an intracellular domain) that may explain the resistant ...
G, Pan, J, Ni, Y F, Wei, G, Yu, R, Gentz, V M, Dixit   +5 more
openaire   +2 more sources

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

Nature, 2013
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and inflammation. These cytokines are recognized by members of the TNF receptor (TNFR) family of death receptors, including TNFR1 and TNFR2, and FAS and TNF-related apoptosis-inducing ligand (TRAIL) receptors.
Shan, Li, Li, Zhang, Qing, Yao, Lin, Li, Na, Dong, Jie, Rong, Wenqing, Gao, Xiaojun, Ding, Liming, Sun, Xing, Chen, She, Chen, Feng, Shao   +11 more
openaire   +2 more sources

Role of NMDA receptor functional domains in excitatory cell death

Neuropharmacology, 2000
The mechanisms by which the NMDA receptor (NMDAR) induces excitotoxicity were investigated using a novel assay. We quantitated the capacity of wild type and mutant receptors for cell killing in CHO cells and cultured cortical neurons by measuring the activity of a co-transfected firefly luciferase expression plasmid.
G A, Rameau, Y, Akaneya, L, Chiu, E B, Ziff   +3 more
openaire   +2 more sources

Solution structure of the tumor necrosis factor receptor-1 death domain

Journal of Molecular Biology, 2001
Tumor necrosis factor receptor-1 death domain (TNFR-1 DD) is the intracellular functional domain responsible for the receptor signaling activities. The solution structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy. A total of 20 structures were calculated by means of hybrid distance geometry-simulated annealing using a total of ...
S F, Sukits, L L, Lin, S, Hsu, K, Malakian, R, Powers, G Y, Xu   +5 more
openaire   +2 more sources

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

Science, 1999
Tumor necrosis factor receptor type 1 (TNF-R1) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear factor kappa B (NF-κB) activation. Normally, these signals are generated only after TNF-induced receptor aggregation.
Y, Jiang, J D, Woronicz, W, Liu, D V, Goeddel   +3 more
openaire   +2 more sources

Death Effector Domain-Only Polypeptides of Caspase-8 and -10 Specifically Inhibit Death Receptor-Induced Cell Death

Biochemical and Biophysical Research Communications, 2002
Caspase-8 and -10 are thought to be involved in a signaling pathway leading to death receptor-mediated apoptosis. The prodomains of these caspases are known to form fibrous structures in the perinuclear region when overexpressed, though the meaning of the structures remains unclear.
Yoshiaki, Shikama, Lisong, Shen, Motokuni, Yonetani, Jun, Miyauchi, Toshiyuki, Miyashita, Masao, Yamada   +5 more
openaire   +2 more sources

Death domain receptors and their role in cell demise.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 1998
Apoptotic signals are transduced by five death domain-containing receptors--TNFR1, Fas, DR3, DR4, and DR5--by binding to their ligands. The intracellular portion of all these receptors contains a region, approximately 80 amino acids long, referred to as the "death domain" (DD).
A, Singh, J, Ni, B B, Aggarwal
openaire   +1 more source

Suppression of receptor-mediated apoptosis by death effecter domain recruiting domain binding peptide aptamer

Biochemical and Biophysical Research Communications, 2006
FLASH protein is a component of death-inducing signaling complex and might be involved in death receptor-mediated extrinsic apoptosis. Here we developed the peptide aptamer against death effecter domain recruiting domain (DRD) of FLASH protein and showed that the peptide bound to FLASH protein in vitro.
Gab Seok, Kim, Young Ae, Park, Yong Seok, Choi, Yun-Hee, Choi, Hyun Woo, Choi, Yong-Keun, Jung, Sunjoo, Jeong   +6 more
openaire   +2 more sources

The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling

2004
The role of p75 neurotrophin receptor (p75NTR) in mediating cell death is now well characterized, however, it is only recently that details of the death signaling pathway have become clearer. This review focuses on the importance of the juxtamembrane Chopper domain region of p75NTR in this process.
Coulson, E., Reid, K. M., Shipham, K. M., Morley, S. N., Kilpatrick, T. J., Bartlett, P. F.   +5 more
openaire   +4 more sources