Results 21 to 30 of about 2,499,152 (288)

Dopamine receptors in schizophrenia

The Lancet, 1995
Udgivelsesdato: 1995-Nov ...
Albert Gjedde, Albert Gjedde, Albert Gjedde, Jakob Reith, Jakob Reith, Jakob Reith, Dean Wong, Dean Wong, Dean Wong   +8 more
openaire   +3 more sources

Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors

Frontiers in Pharmacology, 2020
In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gαi/o-coupled dopamine D2-like receptors (D2R, D3R, D4R) have previously been ...
Richard Ågren, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm   +3 more
doaj   +1 more source

M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. [PDF]

PLoS ONE, 2011
Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so mainly by inhibiting GABA neurons near the ventral tegmental area (VTA), in turn leading to a disinhibition of dopamine neurons.
Stephan Steidl, Anthony D Miller, Charles D Blaha, John S Yeomans   +3 more
doaj   +1 more source

Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

npj Schizophrenia, 2017
Antipsychotic drugs are widely prescribed medications, used for numerous psychiatric illnesses. However, antipsychotic drugs cause serious metabolic side effects that can lead to substantial weight gain and increased risk for type 2 diabetes.
Zachary Freyberg, Michael J. McCarthy
doaj   +1 more source

Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients

BMC Medical Genetics, 2001
Background Though the dysfunction of central dopaminergic system has been proposed, the etiology or pathogenesis of schizophrenia is still uncertain partly due to limited accessibility to dopamine receptor. The purpose of this study was to define whether
Choi Chul-Hee, Koo Min-Seong, Kwak Yong T, Sunwoo IN   +3 more
doaj   +1 more source

Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions

Pharmaceuticals, 2023
Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement.
Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Chiara Cervetto, Raffaele De Caro, Guido Maura, Luigi F. Agnati   +6 more
doaj   +1 more source

Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose

Translational Psychiatry, 2016
Although all current antipsychotics act by interfering with the action of dopamine at dopamine D2 receptors, two recent reports showed that 800 to 1000 mg of cannabidiol per day alleviated the signs and symptoms of schizophrenia, although cannabidiol is ...
P. Seeman
semanticscholar   +1 more source

In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug

Scientific Reports, 2018
PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-
Yanan Xu, Xiaoyin Zhu, Hongbo Wang, Shanyue Sun, Xin Yue, Jingwei Tian   +5 more
doaj   +1 more source

Dopamine: Receptors, Functions, Synthesis, Pathways, Locations andMental Disorders: Review of Literatures

, 2016
Dopamine is monoamine neurotransmitter. Dopamine is produced in the dopaminergic neurons in the ventral tegmental area of the substantia nigra, midbrain and the arcuate nucleus of the hypothalamus.
G. Ayano
semanticscholar   +1 more source

Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior

Nature Communications, 2023
The role of dopamine in the cerebellum remains relatively unexplored. Here, the authors report a dopamine system in the cerebellum in mice, where Purkinje cells supply dopamine and Bergmann glia express D1 receptors.
Chang Li, Natalie B. Saliba, Hannah Martin, Nicole A. Losurdo, Kian Kolahdouzan, Riyan Siddiqui, Destynie Medeiros, Wei Li   +7 more
doaj   +1 more source