Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data
Mengmeng Liu+15 more
doaj +1 more source
Normal spatial learning and improved spatial working memory in mice (mus musculus) lacking dopamine d4 receptors [PDF]
Dopamine terminals in the hippocampus and prefrontal cortex modulate cognitive processes such as spatial learning and working memory. Because dopamine D4 receptors are expressed in these brain areas we have analyzed mutant mice lacking this receptor ...
Avale, Maria Elena+3 more
core +1 more source
Dopamine is monoamine neurotransmitter. Dopamine is produced in the dopaminergic neurons in the ventral tegmental area of the substantia nigra, midbrain and the arcuate nucleus of the hypothalamus.
G. Ayano
semanticscholar +1 more source
Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior
The role of dopamine in the cerebellum remains relatively unexplored. Here, the authors report a dopamine system in the cerebellum in mice, where Purkinje cells supply dopamine and Bergmann glia express D1 receptors.
Chang Li+7 more
doaj +1 more source
Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats [PDF]
Stress-induced reinstatement of cocaine seeking requires corticotropin releasing factor (CRF) actions in the ventral tegmental area (VTA). However the mechanisms through which CRF regulates VTA function to promote cocaine use are not fully understood ...
Baker, David A.+5 more
core +2 more sources
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor
Dopamine is an essential neurotransmitter, which functions are mediated by five G protein-coupled receptors, dopamine D1 to D5 receptors (D1R-D5R) in mammals.
Y. Zhuang+14 more
semanticscholar +1 more source
Relationship of Alexithymia Ratings to Dopamine D2-type Receptors in Anterior Cingulate and Insula of Healthy Control Subjects but Not Methamphetamine-Dependent Individuals. [PDF]
BackgroundIndividuals with substance-use disorders exhibit emotional problems, including deficits in emotion recognition and processing, and this class of disorders also has been linked to deficits in dopaminergic markers in the brain.
Ghahremani, Dara G+5 more
core +2 more sources
Interactions between Histamine H1 and H3 and Dopamine D1 Receptors on feeding behavior in chicken [PDF]
BACKGROUND: Brain monoamines (such as histamine and dopamine) play an important role in emotions, cognition, reward and feeding behavior. The interactions between histamine and dopamine were studied in many physiological functions but this correlation is
Masood GhandForoushan+2 more
doaj +1 more source
The Dopamine/Neuroleptic Receptor [PDF]
ABSTRACTThe neuroleptic/dopamine receptor, with its picomolar affinity for potent neuroleptics, is the functional dopamine receptor of the brain. This receptor has been termed the D2dopamine receptor, and it inhibits or interferes with dopamine-stimulated adenylate cyclase.
Dimitri Grigoriadis, Philip Seeman
openaire +3 more sources
Dopamine modulation of avoidance behavior in Caenorhabditis elegans requires the NMDA receptor NMR-1. [PDF]
The nematode C. elegans utilizes a relatively simple neural circuit to mediate avoidance responses to noxious stimuli such as the volatile odorant octanol. This avoidance behavior is modulated by dopamine.
Melvin Baidya+3 more
doaj +1 more source