Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells [PDF]
, 2004 The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist.
Grandage, V.L. +3 more
core +1 more source
Localization of Erythropoietin and Erythropoietin‐Receptor in Postimplantation Mouse Embryos [PDF]
Development, Growth & Differentiation, 1993 We used RT‐PCR (reverse transcription‐polymerase chain reaction) and immunocytochemical methods to demonstrate the presence of erythropoietin (Ep) and its receptor (EpR) in postimplantation mouse embryos from the egg‐cylinder to the unturned stage. Expression of mRNA for EpR was detected in total RNA from embryos and decidua in all these stages, but Ep
Yoshiko, Yasuda +6 more
openaire +2 more sources
Adding epoetin alfa to intense dose-dense adjuvant chemotherapy for breast cancer : randomized clinical trial [PDF]
, 2013 BACKGROUND: The AGO-ETC trial compared 5-year relapse-free survival of intense dose-dense (IDD) sequential chemotherapy with epirubicin (E), paclitaxel (T), and cyclophosphamide (C) (IDD-ETC) every 2 weeks vs conventional scheduled epirubicin ...
Bois, Andreas du +13 more
core +1 more source
Retrovirology, 2010 Background The ability to efficiently and selectively target gene delivery vectors to specific cell types in vitro and in vivo remains one of the formidable challenges in gene therapy.
Marino Michael P +5 more
doaj +1 more source
The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review
Frontiers in Pharmacology, 2022 Numerous studies explored the therapeutic effects of erythropoietin (EPO) on neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of EPO treatment for ischemic stroke.
Yuanyuan Ma +5 more
doaj +1 more source
Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro [PDF]
, 1993 Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation.
Eckardt, Kai-Uwe +3 more
core +1 more source
A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility
BMC Biotechnology, 2023 Background Dysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intestine in various injury models. While
Prem Kumar Govindappa +5 more
doaj +1 more source
Definition of a family of tissue-protective cytokines using functional cluster analysis: a proof-of-concept study [PDF]
, 2014 The discovery of the tissue-protective activities of erythropoietin (EPO) has underlined the importance of some cytokines in tissue-protection, repair, and remodeling.
Annenkov, Alexander +4 more
core +3 more sources
The use of genes for performance enhancement: doping or therapy? [PDF]
, 2011 Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility of using genetic manipulation ...
Collares, T. F. +4 more
core +5 more sources
Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway
Pharmaceuticals, 2020 Erythropoietin-producing hepatocellular carcinoma A (EphA) receptors and their ephrin-A ligands are key players of developmental events shaping the mature organism. Their expression is mostly restricted to stem cell niches in adults but is reactivated in
Sarah Baudet +2 more
doaj +1 more source