Results 61 to 70 of about 38,806 (274)

Recruitment of endogenous progenitor cells by erythropoietin loaded particles for in situ cartilage regeneration

Bioactive Materials, 2020
Cartilage injury affects millions of people throughout the world, and at this time there is no cure. While transplantation of stem cells has shown some success in the treatment of injured cartilage, such treatment is limited by limited cell sources and ...
Amirhossein Hakamivala, Shuxin li, Kayti Robinson, YiHui Huang, Shuai Yu, Baohong Yuan, Joseph Borrelli, Jr., Liping Tang   +7 more
doaj   +1 more source

Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain

Acta Neuropathologica, 2001
Using immunohistochemistry, expression of erythropoietin (EPO), a hypoxia-inducible neuroprotective factor, and its receptor (EPOR) were investigated in human brain tissue after ischemia/hypoxia. Autopsy brains of neuropathologically normal subjects were compared to those with ischemic infarcts or hypoxic damage.
Siren, A. L., Knerlich, F., Poser, Wolfgang, Gleiter, Christoph H., Bruck, Wolfgang W., Ehrenreich, Hannelore   +5 more
openaire   +3 more sources

Erythropoietin receptors: their role beyond erythropoiesis [PDF]

Nephrology Dialysis Transplantation, 2005
It has been known for 40 years that erythropoietin, which is mainly produced by the kidney in response to hypoxia, is the primary regulator of red blood cell production and is indispensable for terminal differentiation of erythroid progenitors. It controls proliferation, maturation and also survival of erythroid progenitor cells.
Jerome, Rossert, Kai-Uwe, Eckardt
openaire   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

C-FGF23 peptide alleviates hypoferremia during acute inflammation

Haematologica, 2020
Hypoferremia results as an acute phase response to infection and inflammation aiming to reduce iron availability to pathogens. Activation of toll-like receptors (TLRs), the key sensors of the innate immune system, induces hypoferremia mainly through the
Rafiou Agoro, Min Young Park, Carole Le Henaff, Stanislovas Jankauskas, Alina Gaias, Gaozhi Chen, Moosa Mohammadi, Despina Sitara   +7 more
doaj   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis [PDF]

, 2013
Erythropoietin (Epo) is used in clinical settings to enhance hematopoietic function and to improve the quality of life for patients undergoing chemotherapy by reducing fatigue and the need for transfusions.
Berry, Janice E., Jung, Younghun, McGee, Samantha, McGregor, Natalie, Pienta, Kenneth J., Pienta, Michael J., Shiozawa, Yusuke, Taichman, Russell S., Wang, Jingcheng, Yumoto, Kenji   +9 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria

Malaria Journal, 2009
Background Facilitation of endogenous neuroprotective pathways, such as the erythropoietin (Epo) pathway, has been proposed as adjuvant treatment strategies in cerebral malaria. Whether different endogenous protein expression levels of Epo or differences
White Nicholas J, Hien Tran, Day Nicholas PJ, Medana Isabelle M, Turner Gareth DH   +4 more
doaj   +1 more source

Ryanodine receptors are targeted by anti-apoptotic Bcl-X-L involving its BH4 domain and Lys87 from its BH3 domain [PDF]

, 2015
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca2+-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors ...
Bultynck, Geert, De Smedt, Humbert, Decrock, Elke, Ivanova, Hristina, Kasri, Nael Nadif, Lemmens, Irma, Leybaert, Luc, Martens, Lennart, Missiaen, Ludwig, Monaco, Giovanni, Parys, Jan B, Sorrentino, Vincenzo, Tavernier, Jan, Vandermarliere, Elien, Vervliet, Tim   +14 more
core   +1 more source