Results 1 to 10 of about 153,756 (264)

Fc receptors act as innate immune receptors during infection?

Frontiers in Immunology, 2023
Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response.
Chaimaa Laassili, Fatiha Ben El Hend, Riad Benzidane, Loubna Oumeslakht, Abdel-Ilah Aziz, Rachid El Fatimy, Armand Bensussan, Armand Bensussan, Armand Bensussan, Sanae Ben Mkaddem   +9 more
doaj   +1 more source

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Frontiers in Immunology, 2021
Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region.
Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Seth H. Pincus, Gestur Vidarsson, Margaret E. Ackerman, Margaret E. Ackerman   +11 more
doaj   +1 more source

Fc-engineered antibodies with immune effector functions completely abolished.

PLoS ONE, 2021
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors (FcγR) is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins.
Ian Wilkinson, Stephen Anderson, Jeremy Fry, Louis Alex Julien, David Neville, Omar Qureshi, Gary Watts, Geoff Hale   +7 more
doaj   +1 more source

The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit

Pathogens, 2020
Fc gamma receptors (FcγRs) are widely expressed on a variety of immune cells and play a myriad of regulatory roles in the immune system because of their structural diversity.
Thamer A. Hamdan, Philipp A. Lang, Karl S. Lang   +2 more
doaj   +1 more source

Human mast cell activation through Fc receptors and Toll-like receptors

Allergology International, 2004
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE.
Yoshimichi Okayama, Shigeru Okumura, Hisashi Tomita, Hiroko Katayama, Keisuke Yuki, Shinji Kagaya, Jun-ichi Kashiwakura, Hirohisa Saito   +7 more
doaj   +1 more source

A homogeneous bioluminescent immunoassay for parallel characterization of binding between a panel of antibodies and a family of Fcγ receptors

Scientific Reports, 2022
Fc engineering efforts are increasingly being employed to modulate interaction of antibodies with variety of Fc receptors in an effort to improve the efficacy and safety of the therapeutic antibodies.
Nidhi Nath, Becky Godat, Rod Flemming, Marjeta Urh   +3 more
doaj   +1 more source

Pentraxins and Fc Receptor-Mediated Immune Responses

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago.
Jinghua Lu, Carolyn Mold, Carolyn Mold, Terry W. Du Clos, Peter D. Sun   +4 more
doaj   +1 more source

Multimerization strategies for efficient production and purification of highly active synthetic cytokine receptor ligands.

PLoS ONE, 2020
Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner, Hoang T Phan, Saskia Triller, Jens M Moll, Udo Conrad, Jürgen Scheller   +5 more
doaj   +1 more source

IgA Fc Receptors

Annual Review of Immunology, 2003
The IgA receptor family comprises a number of surface receptors including the polymeric Ig receptor involved in epithelial transport of IgA/IgM, the myeloid specific IgA Fc receptor (FcαRI or CD89), the Fcα/μR, and at least two alternative IgA receptors.
Monteiro, R.C., van de Winkel, J.G.J.
openaire   +3 more sources

Fc Receptors

, 2008
The aggregation of cell surface Fc receptors by immune complexes induces a number of important antibody-dependent effector functions. It is becoming increasingly evident that the organization of key immune proteins has a significant impact on the function of these proteins.
Maree S, Powell, P Mark, Hogarth
  +6 more sources