Results 11 to 20 of about 153,756 (264)

Changes in the Interaction Properties of Antibodies with Fc Receptors upon Binding to Target Antigens [PDF]

Biosensors
The interaction of therapeutic antibodies with Fc receptors is an important property that is actively modified to improve pharmacokinetic profiles and optimize antibody-dependent mechanisms of action.
Artem S. Grevtsev, Anton A. Kommer, Irina S. Zelmanchuk, Andrei S. Avdiushkin, Elizaveta O. Ermolaeva, Aleksandr A. Tiulin, Darya O. Chernyshova, Alexandra D. Azarian, Alexandr A. Gordeev, Aleksey K. Misorin   +9 more
doaj   +2 more sources

Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV [PDF]

Cell Reports
Summary: Antibodies binding cell-surface antigens to activate cellular immunity are an important mechanism of anti-viral protection, yet antibodies targeting cells infected by human cytomegalovirus (HCMV) exhibit limited efficacy.
Ahlam N. Qerqez, Katja Hoffmann, Alison G. Lee, Sumit Pareek, Kelli Hager, Akaash K. Mishra, George Delidakis, Kirsten Bentley, Lauren Kerr-Jones, Mica Cabrera, Truong Nguyen, Rebecca L. Göttler, Amjad Chowdhury, Philipp L. Kolb, Hartmut Hengel, George Georgiou, Jason S. McLellan, Richard J. Stanton, Annalee W. Nguyen, Jennifer A. Maynard   +19 more
doaj   +2 more sources

Inside-Out Control of Fc-Receptors

Frontiers in Immunology, 2019
Receptors recognizing the Fc-part of immunoglobulins (FcR) are important in the engagement of phagocytes with opsonized micro-organisms, but they also play a major role in the pathogenesis of chronic inflammatory diseases. Different FcRs are specifically
Leo Koenderman
doaj   +1 more source

Immunoglobulin G1 binding with various molecular receptors: A new paradigm of IgG1 as a potential adjuvant

Journal of Acute Disease, 2019
Objective: To explore the possible IgG1 binding receptors by protein-protein docking experiments. Methods: The protein-protein cognate interactions such as IgG with Fc Receptors (FcRs) potentiate signaling cascades to ameliorate antigen uptake ...
Shweta Saxena, Vignesh Sounderrajan, Saravanan Konda Mani, Shakila Harshavardhan   +3 more
doaj   +1 more source

Enhanced metabolism of LDL aggregates mediated by specific human monocyte IgG Fc receptors.

Journal of Lipid Research, 1995
Macrophage-derived foam cells are important constituents of atheromatous lesions. In addition to the scavenger receptor pathway, uptake of immune complexed lipoproteins through IgG Fc receptors (Fc gamma receptors) represents an additional pathway of ...
P M Morganelli, R A Rogers, T J Kitzmiller, A Bergeron   +3 more
doaj   +1 more source

Effect of IgG dimer concentration on the binding ability of IgG Fc fragment in IVIG to THP-1 cell surface receptors

Zhongguo shuxue zazhi, 2023
Objective To investigate the effect of immunoglobulin G (IgG) dimer concentration of intravenous immunoglobulin (IVIG) on the binding ability of IgG Fc fragment to THP-1 cell surface receptors.
Tingting LEI, Wei ZHANG, Changqing LI, Shengliang YE, Xi DU, Li MA   +5 more
doaj   +1 more source

On the complexity of IgE: The role of structural flexibility and glycosylation for binding its receptors

Frontiers in Allergy, 2023
It is well established that immunoglobulin E (IgE) plays a crucial role in atopy by binding to two types of Fcε receptors (FcεRI and FcεRII, also known as CD23).
Kevin Plattner, Kevin Plattner, Martin F. Bachmann, Martin F. Bachmann, Martin F. Bachmann, Monique Vogel, Monique Vogel   +6 more
doaj   +1 more source

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

eLife, 2018
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknown ...
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James   +14 more
doaj   +1 more source

Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

Cell Reports Medicine, 2021
Summary: Recently approved vaccines have shown remarkable efficacy in limiting SARS-CoV-2-associated disease. However, with the variety of vaccines, immunization strategies, and waning antibody titers, defining the correlates of immunity across a ...
Matthew J. Gorman, Nita Patel, Mimi Guebre-Xabier, Alex L. Zhu, Caroline Atyeo, Krista M. Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jr., Jing-Hui Tian, Dansu Yuan, Kathryn A. Bowman, Bin Zhou, Sonia Maciejewski, Marisa E. McGrath, James Logue, Matthew B. Frieman, David Montefiori, Colin Mann, Sharon Schendel, Fatima Amanat, Florian Krammer, Erica Ollmann Saphire, Douglas A. Lauffenburger, Ann M. Greene, Alyse D. Portnoff, Michael J. Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Galit Alter   +30 more
doaj   +1 more source

Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2

Frontiers in Immunology, 2021
FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic activity of many monoclonal antibody therapies.
Bruce D. Wines, Bruce D. Wines, Bruce D. Wines, Halina M. Trist, Sandra Esparon, Rachael E. Impey, Graham A. Mackay, Robert K. Andrews, Tatiana P. Soares da Costa, Geoffrey A. Pietersz, Geoffrey A. Pietersz, Ross I. Baker, Ross I. Baker, P. Mark Hogarth, P. Mark Hogarth, P. Mark Hogarth   +15 more
doaj   +1 more source