Results 141 to 150 of about 238,537 (264)

Imaging methods to monitor and quantify cell differentiation. [PDF]

Front Cell Dev Biol
Cheah K, Chu P, Schmidt G, Scarlata S.
europepmc   +1 more source

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

Advanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo   +10 more
wiley   +1 more source

Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor. [PDF]

Cell Commun Signal
Ciura K, Sobota O, Chorążewska A, Krowarsch D, Porębska N, Opaliński Ł.   +5 more
europepmc   +1 more source

CLDN18.2 CAR‐derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer

Advanced Healthcare Materials, EarlyView.
CLDN18.2 CAR‐T cell‐derived small extracellular vesicles (CAR‐sEVs) display potent cytotoxicity and prolong survival in preclinical pancreatic cancer models. They contain functional CAR proteins and granzyme B, exhibit antigen specificity, and effectively target tumor cells while sparing healthy cells.
Yue Qing, Ke Jiang, Hua Jiang, Yaru Zhao, Chu‐Hu Lai, Alexandra Aicher, Zonghai Li, Christopher Heeschen   +7 more
wiley   +1 more source

Multifaceted role of heparin in oncology: from anticoagulation to anticancer mechanisms and clinical implications. [PDF]

Discov Oncol
Koirala N, Poudel M, Shrivastava AK, Subba RK, Panthi M, Paudel S, Almarhoon ZM, Sharifi-Rad J, Calina D.   +8 more
europepmc   +1 more source

Light‐Activatable Hyaluronic Acid‐Derivatives Releasing Nitric Oxide and Their Delivery in the Skin

Advanced Healthcare Materials, EarlyView.
This work explores the development of photoactivatable hyaluronic acid (HA) derivatives functionalized with nitric oxide (NO) photodonors for light‐controlled therapeutic applications. The HA derivatives demonstrate enhanced keratinocyte proliferation and migration, effective NO release, and skin penetration when formulated as microemulsions.
Giuseppe Longobardi, Cristina Parisi, Federica Sodano, Ovidio Catanzano, Anna Di Porzio, Antonio Randazzo, Salvatore Sortino, Fabiana Quaglia   +7 more
wiley   +1 more source

Efficacy of 2 different fibroblast growth factor receptor-inhibitors in a patient with extrahepatic cholangiocarcinoma harboring an FGFR2 mutation: a case report. [PDF]

Oncologist
Galli-Vareia I, Szturz P, Voutsadakis IA, Villard N, Tsoumakidou G, Fleury M, Herrera G, Fasquelle F, Godat S, Digklia A.   +9 more
europepmc   +1 more source

Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors

Advanced Healthcare Materials, EarlyView.
Engineered exosome‐based heavy atom‐free nanosensitizers are developed for safe and targeted sono‐photodynamic therapy of solid tumors. The IR820‐TPE‐loaded, biotin‐conjugated exosomes (IR820‐TPE@B‐Exo) demonstrate significant promise for NIR fluorescence imaging‐guided sono‐photodynamic cancer therapy.
Van‐Nghia Nguyen, Thuy Giang Nguyen Cao, Hyunsun Jeong, Quan Truong Hoang, Binh T. T. Pham, Jieun Bang, Chang Woo Koh, Ji Hee Kang, Jeong Hyun Lee, Xiaofeng Wu, Won Jong Rhee, Young Tag Ko, K. M. K. Swamy, Sungnam Park, JaeHong Park, Min Suk Shim, Juyoung Yoon   +16 more
wiley   +1 more source

Mesenteric Fibrosis in Neuroendocrine Neoplasms: a Systematic Review of New Thoughts on Causation and Potential Treatments. [PDF]

Curr Oncol Rep
Spyroglou A, Violetis O, Iliakopoulos K, Vezakis A, Alexandraki K.   +4 more
europepmc   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source