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Cellular signaling by fibroblast growth factor receptors
Cytokine & Growth Factor Reviews, 2005The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4.
V P, Eswarakumar +2 more
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Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium
Brain Research, 2001 Basic fibroblast growth factor (FGF2) stimulates proliferation of the globose basal cells, the neuronal precursor in the olfactory epithelium. The present study investigates the expression of basic fibroblast growth factor and fibroblast growth factor receptors in the adult olfactory epithelium.
Hsu, P +5 more
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Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Candice, Wakulich +3 more
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Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Candice, Wakulich +3 more
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Fibroblast growth factors and their receptors
Biochemistry and Cell Biology, 1997 Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably.
Z, Galzie, A R, Kinsella, J A, Smith
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Receptors for fibroblast growth factors
Immunology & Cell Biology, 1995SummaryThe recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors (FGFR) has led to an intensification of study of this field. It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors (FGF) must bind in order to successfully activate the ...
J C, Coutts, J T, Gallagher
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Targeting the fibroblast growth factor receptor family in cancer.
Cancer Treatment Reviews, 2016 Fibroblast growth factors (FGFs) regulate a plethora of biological functions, in both the embryonic and adult stages of development, binding their cognate receptors and thus activating a variety of downstream signalling pathways.
Niamh Hallinan +5 more
semanticscholar +2 more sources
Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs
Recent Patents on Cardiovascular Drug Discovery, 2006Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). In particular, the two prototypic members of FGF family, namely FGF1 and FGF2, due to their potent mitogenic and pro-migratory activities, have the ability to induce metabolic and phenotypic changes in ECs that ...
Gregory J, Chen, Reza, Forough
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Receptors | Fibroblast Growth Factor Receptors and Cancer-Associated Perturbations
Encyclopedia of Biological Chemistry III, 2013Fibroblast growth factors (FGFs) are heparin-binding polypeptides involved in many important developmental processes including tissue patterning. FGFs act by binding to specific FGF receptors (FGFRs) that possess an intracellular kinase domain.
M. Kornmann, M. Korc
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Fibroblast Growth Factor Receptor Inhibitors
Current Pharmaceutical Design, 2012Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates.
Suneel B V S, Kumar +4 more
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Diverse receptors for fibroblast growth factors
Progress in Growth Factor Research, 1992The development and maintenance of multicellular organisms requires a complex interplay between cells in different tissues. Many of the factors mediating cell-cell communication are polypeptides, which were originally identified because of their ability to stimulate cell growth.
J, Partanen +4 more
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