Results 291 to 300 of about 535,197 (344)
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Promiscuity of fibroblast growth factor receptors
BioEssays, 1996AbstractFibroblast growth factor receptors (FGFRs) have been implicated in many developmental and regenerative events, including axial organisation, mesodermal patterning, keratinocyte organisation and brain development. The consensus view that this reflects a role for one or other of the nine known members of the fibroblast growth factor family in ...
P J, Green, F S, Walsh, P, Doherty
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Fibroblast growth factors and their receptors in cancer
Biochemical Journal, 2011FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life. Deregulation of FGFR signalling, on the other hand, has been associated with many developmental syndromes, and with human cancer.
Jørgen, Wesche +2 more
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Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling
Thrombosis and Haemostasis, 1999A Brief Introduction to the Fibroblast Growth Factor Gene Family The fibroblast growth factor (FGF) family of genes presently comprise 18 members, including the two prototypes, FGF-1 (acidic) and FGF-2 (basic). Although the FGF prototypes are well described as mediators of a variety of diverse biological responses, such as mesoderm induction ...
R, Friesel, T, Maciag
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Journal of Neurochemistry, 2007
AbstractA series of peptides, termed dekafins, were derived from the β10–β11 loop regions of fibroblast growth factors (FGFs) 1, 2, 3, 5, 6, 8, 9, 10, and 17. The dekafins share a homologous amino acid sequence similar to a sequence in the first fibronectin type III module of the neural cell adhesion molecule. All dekafins were shown by surface plasmon
Li, S.Z. +5 more
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AbstractA series of peptides, termed dekafins, were derived from the β10–β11 loop regions of fibroblast growth factors (FGFs) 1, 2, 3, 5, 6, 8, 9, 10, and 17. The dekafins share a homologous amino acid sequence similar to a sequence in the first fibronectin type III module of the neural cell adhesion molecule. All dekafins were shown by surface plasmon
Li, S.Z. +5 more
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Isoforms of Receptors of Fibroblast Growth Factors
Journal of Cellular Physiology, 2014The breadth and scope of Fibroblast Growth Factor signaling is immense, with documentation of its role in almost every organism and system studied so far. FGF ligands signal through a family of four distinct tyrosine kinase receptors, the FGF receptors (FGFRs).
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Fibroblast Growth Factor 23 and Its Receptors
Therapeutic Apheresis and Dialysis, 2005Abstract: Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Autosomal dominant hypophosphatemic rickets is characterized by hypophosphatemia with inappropriately ...
Xijie, Yu, Kenneth E, White
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Fibroblast Growth Factors and Their Receptors in Parathyroid Disease
World Journal of Surgery, 1998AbstractFibroblast growth factors (FGFs) comprise a family of polypeptide growth factors implicated in the control of proliferation of glandular tissues. The aim of this study was to determine whether FGFs are produced in normal and abnormal parathyroid glands and if these tissues have the potential to respond to this growth factor family.
D, Lambert, C L, Eaton, B J, Harrison
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Fibroblast Growth Factor Receptors
1997Fibroblast growth factor (FGF) was discovered in the 1970s as an activity that stimulates the proliferation of 3T3 cells (1). Currently, FGFs comprise a family of nine structurally related proteins (FGF-1 to -9) (reviewed in 2–6). FGFs are expressed in specific spatial and temporal patterns and are involved in developmental processes, angiogenesis ...
David M. Ornitz, Gabriel Waksman
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Plastic and Reconstructive Surgery, 1998
Craniosynostosis is a common disorder with an unknown etiology. Recent genetic mapping studies have demonstrated a strong linkage between several familial craniosynostotic syndromes and mutations in fibroblast growth factor receptor 1 (FGF-R1) and 2 (FGF-R2).
B J, Mehrara +4 more
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Craniosynostosis is a common disorder with an unknown etiology. Recent genetic mapping studies have demonstrated a strong linkage between several familial craniosynostotic syndromes and mutations in fibroblast growth factor receptor 1 (FGF-R1) and 2 (FGF-R2).
B J, Mehrara +4 more
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Journal of Neuro-Oncology, 1994
Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members, including basic and acidic FGF.
R S, Morrison +6 more
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Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members, including basic and acidic FGF.
R S, Morrison +6 more
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