Results 11 to 20 of about 151,588 (287)

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin [PDF]

, 2016
Functional cross-talk between Tie2 and Integrin signaling pathways is essential to coordinate endothelial cell adhesion and migration in response to the extracellular matrix, yet the mechanisms behind this phenomenon are unclear.
Barton, William A., Dalton, Annamarie C., Papo, Niv, Shlamkovitch, Tomer   +3 more
core   +12 more sources

Enhanced Migratory Capacity of T Lymphocytes in Severe Chagasic Patients Is Correlated With VLA-4 and TNF-α Expression

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosoma cruzi infection in humans leads to progression to chronic chagasic myocarditis (CCM) in 30% of infected individuals, paralleling T cell inflammatory infiltrates in the heart tissue.
Luiz Ricardo Berbert, Florencia Belén González, Silvina Raquel Villar, Carlos Vigliano, Susana Lioi, Juan Beloscar, Oscar Adelmo Bottasso, Suse Dayse Silva-Barbosa, Wilson Savino, Wilson Savino, Wilson Savino, Ana Rosa Pérez   +11 more
doaj   +1 more source

Circulating fibronectin and fibronectin receptor in children with pertussis. [PDF]

Journal of Clinical Pathology, 1994
AIM--To determine concentrations of fibronectin and fibronectin receptor in children with pertussis. METHODS--Concentrations of circulating fibronectin and serum fibronectin receptor were detected in eight children affected by pertussis, eight children with acute upper or lower respiratory tract infections, and in 14 healthy control children.
D, Torre, M, Giola, C, Zeroli, R, Martegani, G, Bonetta, G, Ferrario   +5 more
openaire   +2 more sources

Expression of fibronectin, fibronectin isoforms and integrin receptors in melanocytic lesions [PDF]

British Journal of Cancer, 1995
In vitro studies have demonstrated that fibronectin (FN) can deliver a mitogenic signal to quiescent human melanoma cells and that the alpha 5/beta 1-integrin receptor mediates this stimulus. In view of this finding we have analysed the in vivo expression of FN, and of ED-A and ED-B FN isoforms, in benign and malignant lesions of melanocyte origin.
P G, Natali, M R, Nicotra, F, Di Filippo, A, Bigotti   +3 more
openaire   +2 more sources

Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin. [PDF]

PLoS ONE, 2013
Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ.
Maryada Sharma, Anil Tiwari, Shweta Sharma, Preeti Bhoria, Vishali Gupta, Amod Gupta, Manni Luthra-Guptasarma   +6 more
doaj   +1 more source

Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway

Journal of Neuroinflammation, 2021
Background After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of
Shingo Yoshizaki, Tetsuya Tamaru, Masamitsu Hara, Ken Kijima, Masatake Tanaka, Dai-jiro Konno, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada   +8 more
doaj   +1 more source

Molecular Docking Characterization of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop with Hydroxyapatite

Molecules, 2013
Fibronectin adsorption on biomaterial surfaces plays a key role in the biocompatibility of biomedical implants. In the current study, the adsorption behavior of the 7–10th type III modules of fibronectin (FN-III7–10) in the presence of hydroxyapatite ...
Tailin Guo, Wenyuan Kang, Dongqin Xiao, Rongquan Duan, Wei Zhi, Jie Weng   +5 more
doaj   +1 more source

A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques. [PDF]

, 1992
A point mutation in a highly conserved region of the beta 1 subunit, Asp130 to Ala (D130A) substitution, abrogates the Arg-Gly-Asp (RGD)-dependent binding of alpha 5 beta 1 to fibronectin (FN) without disrupting gross structure or heterodimer assembly ...
Ginsberg, MH, Mandelman, D, Puzon, W, Takada, Y, Ylänne, J   +4 more
core   +2 more sources

HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway

Skeletal Muscle, 2017
Background The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a soluble factor during muscle ...
Mariela Natacha González, Wallace de Mello, Gillian S. Butler-Browne, Suse Dayse Silva-Barbosa, Vincent Mouly, Wilson Savino, Ingo Riederer   +6 more
doaj   +1 more source

Fibronectin binding determinants of the Staphylococcus aureus fibronectin receptor

Journal of Biological Chemistry, 1991
Synthetic peptide analogs mimicking a repeated motif within the Staphylococcus aureus fibronectin receptor inhibit binding of the bacteria to fibronectin (Signäs, C., Raucci, G., Jonsson, K., Lindgren, P. E., Anantharamaiah, G. M., Höök, M., and Lindberg, M. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 699-703). In this study, we have further localized the
M J, McGavin, G, Raucci, S, Gurusiddappa, M, Höök   +3 more
openaire   +2 more sources