Results 111 to 120 of about 18,956 (224)

The impact of endogenous annexin A1 on glucocorticoid control of in ammatory arthritis [PDF]

, 2012
This work was supported by a Wellcome Trust (UK) project grant 083551. SMO is funded by Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP (Grant 2011/00128-1) and Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (Grant ...
Acquisto, FD, Girol, AP, Gray, M, Kornerup, KN, Oliani, SM, Patel, HB, Perretti, M, Pitzalis, C, Sampaio, ALF, Seed, MP   +9 more
core   +2 more sources

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]

, 2018
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P., Donaghy, Dillon, Gibbins, Jonathan M., Kriek, Neline, Osborne, Ashley A., Sage, Tanya, Unsworth, Amanda J.   +6 more
core   +4 more sources

Solubilization and Display of G Protein-Coupled Receptors on Beads for Real-Time Fluorescence and Flow Cytometric Analysis

BioTechniques, 2000
G protein-coupled receptors (GPCR) and cellular signaling elements are prime targets for drug discovery. Sensitive realtime methods that expand the analytical capabilities for these elements can play significant roles in basic research and drug discovery.
L.A. Sklar, J. Vilven, E. Lynam, D. Neldon, T.A. Bennett, E. Prossnitz   +5 more
doaj   +1 more source

Formylated Peptide Receptor Mediated Commensal‐Epithelial Signaling

The FASEB Journal, 2009
Commensal bacteria and/or their products engender beneficial effects on the mammalian gut, including promotion of homeostatic cellular turnover and enhanced wound healing. These bacteria have also been shown to activate the pro‐growth ERK signaling pathway, while having no stimulatory ...
Christy Colleen Wentworth, Rheinallt Jones, Asma Nusrat, Andrew Neish   +3 more
openaire   +1 more source

Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis

Thrombosis Journal
Formyl peptide receptors (FPRs) are members of seven transmembrane G protein-coupled receptors superfamily that exhibit different responses based on the nature of stimulating ligand type. FPRs have been shown to be present in platelets and regulate their
Shatha AlOmar, Joanne L Mitchell, Eman AlZahrani   +2 more
doaj   +1 more source

The FPR2-induced rise in cytosolic calcium in human neutrophils relies on an emptying of intracellular calcium stores and is inhibited by a gelsolin-derived PIP₂-binding peptide

BMC Cell Biology, 2010
Background The molecular basis for neutrophil recognition of chemotactic peptides is their binding to specific G-protein-coupled cell surface receptors (GPCRs).
Dahlgren Claes, Forsman Huamei
doaj   +1 more source

Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts

OncoImmunology, 2018
Multiple soluble factors including proteins (in particular chemokines), non-proteinaceous factors released by dead cells, as well as receptors for such factors (in particular chemokine receptors, formyl peptide receptors and purinergic receptors ...
Gautier Stoll, Jonathan Pol, Vassili Soumelis, Laurence Zitvogel, Guido Kroemer   +4 more
doaj   +1 more source

FPR1: A critical gatekeeper of the heart and brain

Pharmacological Research
G protein-coupled receptors (GPCRs) are currently the most widely focused drug targets in the clinic, exerting their biological functions by binding to chemicals and activating a series of intracellular signaling pathways. Formyl-peptide receptor 1 (FPR1)
Ziyin Zhangsun, Yushu Dong, Jiayou Tang, Zhenxiao Jin, Wangrui Lei, Changyu Wang, Ying Cheng, Baoying Wang, Yang Yang, Huadong Zhao   +9 more
doaj   +1 more source

The sensing of bacteria: emerging principles for the detection of signal sequences by formyl peptide receptors

Biomolecular Concepts, 2016
The ability to detect specific chemical signatures released by bacteria and other microorganisms is a fundamental feature of immune defense against pathogens.
Bufe Bernd, Zufall Frank
doaj   +1 more source

Differential requirement of formyl peptide receptor 1 in macrophages and neutrophils in the host defense against Mycobacterium tuberculosis Infection

Scientific Reports
Formyl peptide receptors (FPR), part of the G-protein coupled receptor superfamily, are pivotal in directing phagocyte migration towards chemotactic signals from bacteria and host tissues.
Tanvir Noor Nafiz, Poornima Sankar, Lokesh K. Mishra, Robert P. Rousseau, Mohd Saqib, Selvakumar Subbian, Suraj P. Parihar, Bibhuti B. Mishra   +7 more
doaj   +1 more source