Results 131 to 140 of about 9,630 (179)

Formyl peptide receptors in bone research

Connective Tissue Research, 2022
The formyl peptide receptor (FPR) participates in the immune response, with roles in infection and inflammation. In this review article, we summarize the current literature on these roles before discussing the function of FPRs in the pathogenesis of musculoskeletal disorders including osteoarthritis (OA), degenerative disc disease (DDD), and rheumatoid
Mark A, Lantieri, Jose, R Perdomo Trejo, Quang, Le, Abhijit, Dighe, Quanjun, Cui, Xinlin, Yang   +5 more
openaire   +2 more sources

Role of Formyl Peptide Receptors in Gastrointestinal Healing

Current Pharmaceutical Design, 2018
The wound healing and the barrier restoration of the gastrointestinal (GI) mucosa must be continuously ensured to allow homeostasis of the gastrointestinal tract and of all the surrounding tissues. Several lines of the evidence report a key role of innate immunity, and in particular of Pattern Recognition Receptors (PRRs), in controlling the ...
Rocco Maurizio Zagari, Rosa Marina Melillo, Amato De Paulis   +2 more
exaly   +9 more sources

Formyl Peptide Receptor Expression in Birds

Immunopharmacology and Immunotoxicology, 2007
N-formyl-methionyl-leucyl-phenylalanine (fMLP) is a major chemotactic factor produced by Escherichia coli and other Gram-negative bacteria. The prototypal human fMLP receptor 1 (FPR1) was cloned in 1990 from a differentiated HL-60 myeloid leukemia cell cDNA library.
PANARO, Maria Antonietta, CIANCIULLI, ANTONIA, LISI, SABRINA, SISTO, MARGHERITA, Acquafredda, A, Mitolo, V.   +5 more
openaire   +3 more sources

Pleiotropic roles of formyl peptide receptors

Cytokine & Growth Factor Reviews, 2001
FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these receptors are thought to play a role in host defense against microbial infection.
Y, Le, J J, Oppenheim, J M, Wang
openaire   +2 more sources

Adaptive Evolution of Formyl Peptide Receptors in Mammals

Journal of Molecular Evolution, 2015
The formyl peptide receptors (FPRs) are a family of chemoattractant receptors with important roles in host defense and the regulation of inflammatory reactions. In humans, three FPR paralogs have been identified (FPR1, FPR2, and FPR3) and may have functionally diversified by gene duplication and adaptive evolution.
Yoshinori, Muto, Stéphane, Guindon, Toshiaki, Umemura, László, Kőhidai, Hiroshi, Ueda   +4 more
openaire   +2 more sources

Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

Trends in Immunology, 2018
Formyl-peptide receptors (FPRs) recognize bacterial and mitochondrial formylated peptides as well as endogenous non-formylated peptides and even lipids. FPRs are expressed on various host cell types but most strongly on neutrophils and macrophages. After the discovery of FPRs on leukocytes, it was assumed that these receptors predominantly govern a ...
Elisabeth, Weiß, Dorothee, Kretschmer
openaire   +2 more sources

The N-Formyl Peptide Receptor

1999
The chemotaxis of phagocytic leukocytes from the blood to tissues identifies the acute (neutrophil) and chronic (macrophages) inflammatory condition (1). This hallmark process is central to host defense against microorganisms, to mediation of the immune response, and to repair of injured tissues. When unregulated, however, it is also the key vehicle of
John S. Mills, Heini M. Miettinen, Michael J. Vlases, Algirdas J. Jesaitis   +3 more
openaire   +1 more source

The Uncoupled State of the Human Formyl Peptide Receptor

Journal of Receptors and Signal Transduction, 1999
The formyl peptide receptor (FPR) has been widely used to study the kinetics of the interaction between ligand, receptor and G protein with real-time fluorescence methods. Because the wild type receptor rapidly signals, and is then desensitized and internalized once occupied by ligand, it has been difficult to study the uncoupled receptor form. We have
T L, Gilbert, E R, Prossnitz, L A, Sklar
openaire   +2 more sources

Receptors for chemotactic formyl peptides as pharmacological targets

International Immunopharmacology, 2002
Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes.
Yingying, Le, Yiming, Yang, Youhong, Cui, Hiroshi, Yazawa, Wanghua, Gong, Cunping, Qiu, Ji Ming, Wang   +6 more
openaire   +2 more sources

Differential Activation of Formyl Peptide Receptor Signaling by Peptide Ligands

Molecular Pharmacology, 2003
Formyl peptide receptor (FPR) and formyl peptide receptor like 1 (FPRL1) play important roles in inflammation and immunity. Stimulation of FPR and FPRL1 initiates a cascade of signaling events, leading to activation of various phagocyte responses, including chemotaxis, superoxide generation, and exocytosis.
Bae, Yoe-Sik, Song, Ji Young, Kim, Youndong, He, Rong, Ye, Richard D., Kwak, Jong-Young, Suh, Pann-Ghill, Ryu, Sung Ho   +7 more
openaire   +3 more sources