Results 141 to 150 of about 9,630 (179)

Formyl Peptide Chemotactic Receptors of Leukocytes and Macrophages

1980
Publisher Summary Polymorphonuclear leukocytes, monocytes, and macrophages play a central role in host defence against invading microorganisms. However, the killing mechanisms employed by these motile cells are effective over short distances and require intimate cell-microorganism contact. A mechanism for ensuring efficient accumulation of phagocytic
J E, Niedel, P, Cuatrecasas
openaire   +2 more sources

Epigenetic regulation of the formyl peptide receptor 2 gene

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016
Lipoxin (LX) A4, a main stop signal of inflammation, exerts potent bioactions by activating a specific G protein-coupled receptor, termed formyl peptide receptor 2 and recently renamed ALX/FPR2. Knowledge of the regulatory mechanisms that drive ALX/FPR2 gene expression is key for the development of innovative anti-inflammatory pharmacology.
SIMIELE, FELICE, RECCHIUTI, ANTONIO, PATRUNO, SARA, PLEBANI, ROBERTO, PIERDOMENICO, ANNA MARIA, CODAGNONE, MARILINA, ROMANO, Mario   +6 more
openaire   +3 more sources

Conformational Aspects of Human Formyl-peptide Receptor Agonists

Arzneimittelforschung, 2011
The conformation of several Met-Ile-Phe-Leu analogues was analyzed using circular dichroism and infra-red absorption. Their effect on human neutrophils was verified by receptor binding assays and measurements of lysozyme release. The results demonstrate that in amphipatic environments the compounds examined can be highly and weakly ordered in beta-turn
DALPIAZ, Alessandro, VERTUANI, Gianni, SCATTURIN, Angelo, VITALI F., VARANI, Katia, SPISANI, Susanna   +5 more
openaire   +3 more sources

Molecular biology for formyl peptide receptors in human diseases

Journal of Molecular Medicine, 2013
Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. The first chemotactic factors structurally defined were N-formyl peptides. Subsequently, numerous ligands were identified to activate formyl peptide receptors (FPRs) that belong to the seven-transmembrane G protein-coupled ...
Yongsheng, Li, Duyun, Ye
openaire   +2 more sources

Targeting formyl peptide receptors to facilitate the resolution of inflammation

European Journal of Pharmacology, 2018
The formyl peptide receptors (FPRs) are G protein coupled receptors that recognize a broad range of structurally distinct pathogen and danger-associated molecular patterns and mediate host defense to infection and tissue injury. It became evident that the cellular distribution and biological functions of FPRs extend beyond myeloid cells and governing ...
János G, Filep, Meriem, Sekheri, Driss, El Kebir   +2 more
openaire   +2 more sources

C5a and formyl peptide receptor regulation on human monocytes

Journal of Leukocyte Biology, 1992
Abstract Regulation of C5a and formyl-methionine-leucine-phenylalanine-lysine (fMLPL) receptors on human monocytes has been studied using fluorescein-conjugated derivatives and flow cytometry. Monocytes have receptors for each of these ligands, as evidenced by their ability to bind specifically biologically active fluorescein derivatives
D E, Van Epps, S J, Simpson, D E, Chenoweth   +2 more
openaire   +2 more sources

The Formyl Peptide Chemotactic Receptor: Cellular Processing of Peptide and Receptor

1983
An integrated series of complex cellular functions of polymorphonuclear leukocytes, monocytes and macrophages comprise the inflammatory response. After recognition of an inflammatory stimulus, these phagocytic cells become adherent, migrate in a directed manner through the blood vessel wall and/or the tissue space, ingest opsonized particulate material,
openaire   +1 more source

Vomeronasal Formyl Peptide Receptors in mammals

2016
This thesis uncovers the genetic accidents that led to the acquisition of Formyl Peptide Receptor gene expression in the vomeronasal system of a rodent lineage that represents about 23% of the mammalian species. We also examined whether the cluster organization of vomeronasal genes is involved in the regulation of their expression with the presence of ...
openaire   +1 more source

Formyl peptide receptors as therapeutic targets in eye disease

Trends in Pharmacological Sciences
Once known only as immune sentinels, formyl peptide receptors (FPRs) have emerged as paradoxical regulators of ocular health, capable of driving injury or repair in a ligand-dependent manner. We discuss FPR signaling in diabetic retinopathy, dry eye disease, and retinitis pigmentosa, highlighting therapeutic opportunities arising from biased receptor ...
Rafael André, da Silva, Shama, Parween, Anna, Howell, Cristiane D, Gil, Maria Natalia, Vergara   +4 more
openaire   +2 more sources

Cellular Processing of the Formyl Peptide Receptor

1983
J E, Niedel, B L, Dolmatch
openaire   +2 more sources