Results 31 to 40 of about 18,956 (224)

Internalization of Formyl Peptide Receptor in Leukocytes Subject to Fluid Stresses [PDF]

, 2010
Human leukocytes retract pseudopods under normal physiologic levels of fluid shear stress even in the absence of any other mediator. To gain more detailed understanding of the mechanisms that regulate this cell behavior, we exposed leukocytes to a steady
Susan S. Su, Geert W. Schmid-Schönbein, MF Coughlin, S Ernst, TA Key, Y Komai, VM Loitto, F Moazzam, HY Shin, S Su, CM Vines, M Xue   +11 more
core   +2 more sources

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

Molecules, 2017
The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and superoxide ...
Hui-Qiong He, Richard D. Ye
doaj   +1 more source

Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis

Molecules, 2021
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation, cartilage damage and bone destruction. Although the pharmacological treatment of RA has evolved over the last few years, the new drugs have serious side ...
Letizia Crocetti, Claudia Vergelli, Gabriella Guerrini, Maria Paola Giovannoni, Liliya N. Kirpotina, Andrei I. Khlebnikov, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Elena Lucarini, Igor A. Schepetkin, Mark T. Quinn   +10 more
doaj   +1 more source

Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]

, 1990
Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland, Wenzel-Seifert, Katharina   +1 more
core   +1 more source

Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis [PDF]

, 2014
Formyl-peptide receptor type 2 (FPR2; also called ALX because it is the receptor for lipoxin A4) sustains a variety of biological responses relevant to the development and control of inflammation, yet the cellular regulation of this G-protein-coupled ...
Babbin, Bennett, Berthouze, Cao, Chiang, Cooray, Dufton, Ernst, Gage, Gilbert, Gorvel, Hanyaloglu, Hanyaloglu, Hislop, Huet, Kam, Key, Key, Key, Lauffer, Le, Lefkowitz, Levy, Maestes, Maxfield, Nathan, Oakley, Pippig, Potter, Rabiet, Reiter, Revankar, Tanowitz, Temkin, Thompson, Thompson, Thompson, Vargas, Vines, Wagener, Yudowski, Zhang   +41 more
core   +2 more sources

Formyl Peptide Receptor 1 and 2 Dual Agonist Inhibits Human Neutrophil Chemotaxis by the Induction of Chemoattractant Receptor Cross-desensitization

Journal of Pharmacological Sciences, 2011
Formyl peptide receptor 1 (FPR1) and FPR2/ALX are known to control neutrophil chemotaxis in response to various ligands. In this study, we investigated the inhibitory mechanism of compound 43 (Cpd43), an FPR1 and FPR2/ALX dual agonist, on human ...
Yoshitaka Sogawa, Takao Ohyama, Hiroaki Maeda, Kazuki Hirahara   +3 more
doaj   +1 more source

Granulocyte activation by danger signals and blocking of receptor responses [PDF]

, 2007
Granulocytes are the most abundant cells in the peripherial blood. They serve to eliminate invading microbes and parasites and release anti-microbial agents. In the event of injury, granulocytes are recruited to damaged tissues.
Stenfeldt, Anna-Lena
core   +1 more source

Functional Characterization of Three Mouse Formyl Peptide Receptors [PDF]

Molecular Pharmacology, 2013
The evolutionary relationship and functional correlation between human formyl peptide receptors (FPRs) and their mouse counterparts remain incompletely understood. We examined three members of the mouse formyl peptide receptor subfamily (mFprs) and found that they differ in agonist preference and cellular distributions.
Hui-Qiong, He, Dan, Liao, Zhen-Guo, Wang, Zhong-Li, Wang, Hu-Chen, Zhou, Ming-Wei, Wang, Richard D, Ye   +6 more
openaire   +2 more sources

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

JACC: Basic to Translational Science, 2019
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and ...
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD   +22 more
doaj   +1 more source

Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression

Life, 2021
G protein-coupled receptors (GPCRs) are the most important regulators of cardiac function and are commonly targeted for medical therapeutics. Formyl-Peptide Receptors (FPRs) are members of the GPCR superfamily and play an emerging role in cardiovascular ...
Valentina Maria Caso, Valentina Manzo, Tiziana Pecchillo Cimmino, Valeria Conti, Pio Caso, Gabriella Esposito, Vincenzo Russo, Amelia Filippelli, Rosario Ammendola, Fabio Cattaneo   +9 more
doaj   +1 more source