Results 51 to 60 of about 18,956 (224)

House dust mite allergen activates human eosinophilsviaformyl peptide receptor and formyl peptide receptor‐like 1 [PDF]

European Journal of Immunology, 2007
AbstractThe objective was to evaluate which receptors house dust mite (HDM) and birch pollen extracts engage to activate human eosinophils. Chemotaxis and degranulation were studied in eosinophils pretreated with pertussis toxin and other antagonists of G protein‐coupled receptors,e.g.the formyl peptide receptor (FPR), CC chemokine receptor 3 (CCR3 ...
Svensson, Lena, Redvall, Elin, Björn, Camilla, Karlsson, Jennie, Bergin, Ann-Marie, Rabiet, Marie-Josèphe, Dahlgren, Claes, Wennerås, Christine   +7 more
openaire   +4 more sources

Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond

Pharmacological Research, 2023
In the aftermath of tissue injury or infection, an efficient resolution mechanism is crucial to allow tissue healing and preserve appropriate organ functioning. Pro-resolving bioactive lipids prevent uncontrolled inflammation and its consequences.
Sergio Sánchez-García, Rafael I. Jaén, María Fernández-Velasco, Carmen Delgado, Lisardo Boscá, Patricia Prieto   +5 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Lipoxin Receptors

The Scientific World Journal, 2007
Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti-inflammatory properties, LXA4 and LXB4 being the main components of this series. LXs are generated by cooperation between 5-lipoxygenase (LO)
Mario Romano, Irene Recchia, Antonio Recchiuti   +2 more
doaj   +1 more source

The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship?

Frontiers in Immunology, 2021
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a progressive symmetric inflammation of the joints resulting in bone erosion and cartilage destruction with a progressive loss of function and joint deformity. An increased number
Ilaria Mormile, Francesca Wanda Rossi, Francesca Wanda Rossi, Nella Prevete, Nella Prevete, Francescopaolo Granata, Valentina Pucino, Amato de Paulis, Amato de Paulis   +8 more
doaj   +1 more source

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. [PDF]

, 2019
The composition of the gastrointestinal microbiota and associated metabolites changes dramatically with diet and the development of obesity. Although many correlations have been described, specific mechanistic links between these changes and glucose ...
Chan, Luisa S, Chordia, Mahendra D, El Ouarrat, Dalila, Han, Andrew W, Jain, Mohit, Johnson, Andrew MF, Lee, Yun Sok, Mahmood, Nadir A, Ofrecio, Jachelle M, Olefsky, Jerrold M, Pan, Dongfeng, Riopel, Matthew, Ryan, Caitlin N, Watrous, Jeramie D, Wollam, Joshua, Xu, Yong-Jiang, Ying, Wei   +16 more
core   +1 more source

Variable responses of formyl peptide receptor haplotypes toward bacterial peptides

Immunogenetics, 2008
The chemoattractant neutrophil formyl peptide receptor (FPR) binds bacterial and mitochondrial N-formylated peptides, which allows the neutrophils to find the bacterial source and/or site of tissue damage. Certain inflammatory disorders may be due in part to an impaired innate immune system that does not respond to acute bacterial damage in a timely ...
Gripentrog, Jeannie M., Mills, John S., Saari, George J., Miettinen, Heini M.   +3 more
openaire   +3 more sources

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease [PDF]

, 2019
Microglia are key players in the pathology of Alzheimer’s disease (AD), driving chronic inflammation, oxidative stress, and the altered metabolism seen in the brains of patients.
Wickstead, E., Wickstead, E.
core  

Differential activation of polymorphisms of the formyl peptide receptor by formyl peptides

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
We have investigated the role of two polymorphic sites (R190W and N192K) on the binding and activation of the formyl peptide receptor (FPR) by viral and formyl peptides. WEDWVGWI, a peptide with antiviral activity derived from the membrane proximal region of feline immunodeficiency virus, binds with high affinity to FPR.
openaire   +3 more sources