Results 1 to 10 of about 159,633 (311)

Computational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor [PDF]

BMC Research Notes, 2012
Background GABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development and fluid homeostasis. However, the
Zhao Chunling, Huang Chaoqun, Weng Tingting, Xiao Xiao, Ma Hong, Liu Lin   +5 more
doaj   +5 more sources

Anaesthetic impairment of immune function is mediated via GABA(A) receptors. [PDF]

PLoS ONE, 2011
GABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs.
Daniel W Wheeler, Andrew J Thompson, Federico Corletto, Jill Reckless, Justin C T Loke, Nicolas Lapaque, Andrew J Grant, Pietro Mastroeni, David J Grainger, Claire L Padgett, John A O'Brien, Nigel G A Miller, John Trowsdale, Sarah C R Lummis, David K Menon, John S Beech   +15 more
doaj   +5 more sources

Intra-accumbens baclofen, but not muscimol, increases second order instrumental responding for food reward in rats. [PDF]

PLoS ONE, 2012
Stimulation of either GABA(A) or GABA(B) receptors within the nucleus accumbens shell strongly enhances food intake in rats. However the effects of subtype-selective stimulation of GABA receptors on instrumental responses for food reward are less well ...
Kim G T Pulman, Elizabeth M Somerville, Peter G Clifton   +2 more
doaj   +13 more sources

Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia. [PDF]

J Chem Inf Model
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agents that offer more precise and controllable effects. Targeting Gamma-aminobutyric acid (GABA) receptors, the primary inhibitory receptors in the central nervous system, could
Jiang J, Chen L, Zhu Y, Shi Y, Qiu H, Zhang B, Zhou T, Wei GW.   +7 more
europepmc   +2 more sources

Stimulation of TM3 Leydig cell proliferation via GABA_A receptors: A new role for testicular GABA [PDF]

Reproductive Biology and Endocrinology, 2004
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABAA and GABAB ...
Krieger Annette, Thalhammer Andrea, Doepner Richard FG, Geigerseder Christof, Mayerhofer Artur   +4 more
doaj   +4 more sources

GABA potency at GABAA receptors found in synaptic and extrasynaptic zones [PDF]

Frontiers in Cellular Neuroscience, 2012
The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen, Bijal ePatel, Trevor G. Smart   +2 more
doaj   +5 more sources

Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. [PDF]

PLoS ONE, 2016
The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABAC receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has
Moawiah M Naffaa, Nathan Absalom, V Raja Solomon, Mary Chebib, David E Hibbs, Jane R Hanrahan   +5 more
doaj   +5 more sources

Membranes and Synaptosomes Used to Investigate Synaptic GABAergic Currents in Epileptic Patients [PDF]

Membranes
Among the most prevalent neurological disorders, epilepsy affects about 1% of the population worldwide. We previously found, using human epileptic tissues, that GABAergic neurotransmission impairment is a key mechanism that drives the pathological ...
Alessandro Gaeta, Lilian Juliana Lissner, Veronica Alfano, Pierangelo Cifelli, Alessandra Morano, Cristina Roseti, Angela Di Iacovo, Eleonora Aronica, Eleonora Palma, Gabriele Ruffolo   +9 more
doaj   +3 more sources

GABA_A and GABA_B Receptors Mediate GABA-Induced Intracellular Ca²⁺ Signals in Human Brain Microvascular Endothelial Cells

Cells, 2022
Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by activating the ionotropic GABAA receptors on cerebrovascular endothelial cells ...
Sharon Negri, Francesca Scolari, Mauro Vismara, Valentina Brunetti, Pawan Faris, Giulia Terribile, Giulio Sancini, Roberto Berra-Romani, Francesco Moccia   +8 more
doaj   +1 more source

Electrophysiology of ionotropic GABA receptors [PDF]

Cellular and Molecular Life Sciences, 2021
AbstractGABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and diverse roles GABAA receptors play in the regulation of neuronal communication and the functioning of the brain.
Erwan Sallard, Diane Letourneur, Pascal Legendre   +2 more
openaire   +5 more sources