Results 191 to 200 of about 604,542 (323)

Differential Effects of Prenatal Poly I:C Exposure and Antipsychotics on NMDA/GABA Receptors and GSK3β-Mediated Signaling in the Dorsal Raphe Nucleus of Female Rats. [PDF]

Fundam Clin Pharmacol
Chen S, Lian J, Su Y, Deng C.
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Benzodiazepine-resistant epilepsy: unraveling molecular mechanisms and developing multimodal therapeutic strategies. [PDF]

Front Neurol
Huang Y, Zhang Y, Liang Y.
europepmc   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

A single main-chain hydrogen bond required to keep GABA_A receptors closed. [PDF]

Nat Commun
Borghese CM, Galpin JD, Eriksson Lidbrink S, Zhuang Y, Desai NG, Howard RJ, Lindahl E, Ahern CA, Goldschen-Ohm MP.   +8 more
europepmc   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Unveiling GABA and Serotonin Interactions During Neurodevelopment to Re-Open Adult Critical Periods for Neuropsychiatric Disorders. [PDF]

Int J Mol Sci
Beretta E, Cuboni G, Deidda G.
europepmc   +1 more source

Agricultural Mulching and Fungicides—Impacts on Structure and Function of the Soil Microbial Community

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Background Plastic mulching and fungicides are frequently applied agricultural practices in strawberry cultivation, which may have an impact on the structure and function of the soil microbiome. Aim To understand their combined effects on soil quality, this study investigated the impact of the fungicides fenhexamid, cyprodinil, and fludioxonil
Maximilian Meyer, Zacharias Steinmetz, Giselle Berenstein, Gabriele Ellen Schaumann, Katherine Muñoz   +4 more
wiley   +1 more source

Microplastics in Agricultural Soil: Fate, Impacts, and Bioremediation by Earthworms

Journal of Plant Nutrition and Soil Science, EarlyView.
Microplastics enter the soil through various means, including the degradation of plastic film mulch, waste from cosmetics industries and municipalities, and the use of bioplastic seed coatings. These microplastics disrupt soil structure, microbial activity, enzyme function, and plant growth.
Sami ur Rehman, Mudassar Hussain, Federica De Castro, Michele Benedetti, Alessio Aprile, Francesco Paolo Fanizzi   +5 more
wiley   +1 more source

Electroacupuncture as adjunctive therapy for insomnia via targeting the GABAergic microbiota-gut-brain axis: a mini review. [PDF]

Front Psychiatry
Wang X, Yan L, Zhang X, Liu X, Yang B.
europepmc   +1 more source