Results 241 to 250 of about 604,542 (323)

Patient‐Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson‐Gilford Progeria Syndrome

Aging Cell, EarlyView.
HGPS patient‐derived cortical organoids exhibit progerin accumulation, nuclear abnormalities, and increased senescence in rosette structures, leading to impaired neuronal differentiation and altered gene expression. ABSTRACT Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature aging and primarily caused by ...
Seeun Jeon, Chul‐Sung Park, Juyoung Hong, Jieun Kim, Yun Jin Lee, Junho K. Hur, Ji Yeoun Lee   +6 more
wiley   +1 more source

Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring. [PDF]

Transl Psychiatry
Li M, Qiao Z, Li J, Zhou H, Huang D, Cai Y, Li X, Zhang Z, Zhou J, Zhou J.   +9 more
europepmc   +1 more source

Rat models of fetal alcohol spectrum disorders for studying the critical role of cerebellar damage: A scoping review

Alcohol, Clinical and Experimental Research, EarlyView.
In rat models used to study the effects of early alcohol exposure on cerebellum function and structure during pregnancy and lactation, the following conclusions can be drawn: (1) Exposure to ethanol during the first and second‐trimester equivalent in humans affects biochemical pathways in the cerebellum, but produces fewer structural changes.
Fátima Nogales, Karick Jotty, Diego Pascual‐Vaca, María del Carmen Gallego‐López, Olimpia Carreras, María Luisa Ojeda   +5 more
wiley   +1 more source

GABA_B receptor activation contributes to post-surgery cognitive impairments in mice by inducing hippocampal BDNF hypermethylation. [PDF]

Ann Med
Wu T, Sun XY, Cao J, Tong K, Hao JR, Sun N, Gao C.   +6 more
europepmc   +1 more source

An exploratory analysis of 5‐alpha reductase inhibitors and risk of opioid use disorder among male Medicare beneficiaries receiving prescription opioid medications

The American Journal on Addictions, EarlyView.
Abstract Background Opioid use disorder (OUD) imposes a significant socioeconomic burden, highlighting the need for new interventions. Objective This study investigated whether exposure to 5‐alpha reductase inhibitors (5αRIs) is associated with a lower risk of developing OUD.
Abdelrahman G. Tawfik, Tyler Lister, Ainhoa Gomez‐Lumbreras, Randall T. Peterson, Marco Bortolato, Daniel C. Malone   +5 more
wiley   +1 more source

Tea and Its Active Ingredients in Preventing and Alleviating Depression: A Comprehensive Review. [PDF]

Foods
Xiao S, Li Y, Jiang H, Hou S, Wang Y, Wang D, Teng J.   +6 more
europepmc   +1 more source

Breast and Nipple Dermatoses During Lactation

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Lactation and breastfeeding can present both psychological and physical challenges for breastfeeding mothers. In addition, many nursing mothers will also suffer from breast and nipple dermatoses during this period, compounding these difficulties. Common causes of breast and nipple dermatitis during lactation include eczema, psoriasis, mastitis,
Hamish Moore, Annabel Stevenson
wiley   +1 more source

From the different pathogenesis of epileptogenesis: vitamins as an adjunctive treatment for epilepsy. [PDF]

Acta Epileptol
Sun W, Wang Y, Xiao B, Luo Z.
europepmc   +1 more source

La femme fait la maison: The Accumulation of Surplus Value through Family Planning in Burkina Faso1

Antipode, EarlyView.
Abstract Since the 1960s, demographers, international donors, and governments have calculated the political, economic, and social benefits of modern contraception usage in West Africa. We evidence how family planning technologies (FPTs) that are tethered to population development extract double value (productive and reproductive labour) from Burkinabè ...
T.D. Harper‐Shipman, Katian Napon
wiley   +1 more source