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GABA-A receptor subtypes, benzodiazepines and feeding
Appetite, 2008Benzodiazepines (BZs) enhance food intake by acting at GABAA receptors which have a pentameric structure consisting of two a, two s and one γ2 subunit. a1, a2, a3, and a5 containing GABAA receptors are sensitive to BZs such as diazepam and midazolam. Cooper (2005) suggested that the effects of BZs on feeding were mediated by a2 or a3 containing GABAA ...
H.V. Morris, D.N. Stephens, P.G. Clifton
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Supersensitivity of GABA-A receptors in hepatic encephalopathy
Neurochemical Research, 1990During the past decade a new approach to pathogenetic studies of hepatic encephalopathy has been undertaken to identify the neurochemical alterations which characterize the syndrome. Using animal models of hepatic encephalopathy electrophysiological, behavioral, pharmacological and biochemical evidence were provided of an increased functional activity ...
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[GABA(A) receptor trafficking and epilepsy].
Nihon rinsho. Japanese journal of clinical medicine, 2014Recent studies clarified a dynamic regulation of the intracellular trafficking of GABA(A) receptors and its involvement in the pathophysiology of epilepsy. GABA(A) synaptic inhibition decreased in the hippocampal CA1 area of patients with intractable temporal lobe epilepsy (TLE).
Eiichi, Maru, Hiroyuki, Ura
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Interaction of Steroids with the GABA-A Receptor
Current Topics in Medicinal Chemistry, 2002Over the last two decades there has been a resurgence of interest in steroids as potential therapeutics for central nervous system disorders. This interest followed the discovery that neurosteroids and neuroactive steroids are potent modulators of GABA(A) receptor function.
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GABAA Receptor Channel Pharmacology
Current Pharmaceutical Design, 2005GABA(A) receptor channels are ubiquitous in the mammalian central nervous system mediating fast inhibitory neurotransmission by becoming permeant to chloride ions in response to GABA. The emphasis of this review is on the rich chemical diversity of ligands that influence GABA(A) receptor function. Such diversity provides many avenues for the design and
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Editing modifies the GABA(A) receptor subunit alpha3.
RNA (New York, N.Y.), 2007Adenosine to inosine (A-to-I) pre-mRNA editing by the ADAR enzyme family has the potential to increase the variety of the proteome. This editing by adenosine deamination is essential in mammals for a functional brain. To detect novel substrates for A-to-I editing we have used an experimental method to find selectively edited sites and combined it with ...
Ohlson, Johan +3 more
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[GABA(A) benzodiazepine receptors and epilepsy].
Wiener klinische Wochenschrift, 1990GABAA-benzodiazepine receptors and epilepsy. gamma-Aminobutyric acid (GABA) is quantitatively one of the most important neurotransmitters in the central nervous system. Since the predominant action of GABA on neurons is inhibitory, activation of GABA receptors, and especially of GABAA receptors, causes an anticonvulsive effect.
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Autoimmune encephalitis and anti‐GAD/GABA‐A receptor antibodies
Epileptic Disorders, 2015Related articles PET-positive extralimbic presentation of anti-glutamic acid decarboxylase antibody-associated encephalitis Authors’ response To the Editor,We refer to the publication of Kojima et al 2014: “PET-positive extralimbic presentation of anti-glutamic acid decarboxylase antibody-associated encephalitis”.
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