Ghrelin receptors in non-mammalian vertebrates [PDF]
Frontiers in Endocrinology, 2013 The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya +2 more
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Ghrelin and Ghrelin Receptor Modulation of Psychostimulant Action [PDF]
Frontiers in Neuroscience, 2013 Ghrelin (GHR) is an orexigenic gut peptide that modulates multiple homeostatic functions including gastric emptying, anxiety, stress, memory, feeding and reinforcement.
Paul Jeff Wellman +2 more
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MOLECULAR EVOLUTION OF GPCRS: Ghrelin/ghrelin receptors [PDF]
Journal of Molecular Endocrinology, 2013 After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
Hiroyuki, Kaiya +2 more
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Mechanisms of Ghrelin anti-heart failure: inhibition of Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R expression. [PDF]
PLoS ONE, 2014 BACKGROUND: Ghrelin is a novel growth hormone-releasing peptide administered to treat chronic heart failure (CHF). However, the underlying mechanism of its protective effects against heart failure (HF) remains unclear.
Chunyan Yang +3 more
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Frontiers in Physiology, 2022 Although increasing research focuses on the phenomenon of body weight gain in women after menopause, the complexity of body weight regulation and the array of models used to investigate it has proven to be challenging.
Kaitlin E. Burch +5 more
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Physiological roles revealed by ghrelin and ghrelin receptor deficient mice [PDF]
Peptides, 2011 Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection.
Rosie G, Albarran-Zeckler +2 more
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Ghrelin axis genes, peptides and receptors : recent findings and future challenges [PDF]
, 2011 The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also ...
Seim, Inge +4 more
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Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]
, 2013 The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre +3 more
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Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
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Ahi Evran Medical Journal, 2023 Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver.
Ahmet TÜRK +4 more
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