Results 41 to 50 of about 27,278 (203)

Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. [PDF]

PLoS ONE, 2012
BackgroundGhrelin is an important regulator of energy--and glucose homeostasis. The octanoylation at Ser(3) is essential for ghrelin's biological effects but the mechanisms involved in the octanoylation are unknown.
Sara Janssen, Jorien Laermans, Hiroshi Iwakura, Jan Tack, Inge Depoortere   +4 more
doaj   +1 more source

Ghrelin Amplifies the Nicotine-Induced Release of Dopamine in the Bed Nucleus of Stria Terminalis (BNST)

Biomedicines, 2023
Ghrelin is an orexigenic neuropeptide that is known for stimulating the release of growth hormone (GH) and appetite. In addition, ghrelin has been implicated in addiction to drugs such as nicotine.
Jázmin Ayman, Miklós Palotai, Roberta Dochnal, Zsolt Bagosi   +3 more
doaj   +1 more source

Attribution of ghrelin to cancer; Attempts to unravel an apparent controversy [PDF]

, 2019
Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute
Khani, Leila, Pastaki Khoshbin, Amin, Roosta, Venus, Sadeghi, Fatemeh, Soleyman-Jahi, Saeed, Zendehdel, Kazem   +5 more
core   +1 more source

The pharmacology and function of receptors for short-chain fatty acids [PDF]

, 2015
Despite some blockbuster G protein–coupled receptor (GPCR) drugs, only a small fraction (∼15%) of the more than 390 nonodorant GPCRs have been successfully targeted by the pharmaceutical industry.
Bolognini, Daniele, Milligan, Graeme, Moss, Catherine E., Tobin, Andrew B.   +3 more
core   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Interruption of Ghrelin Signaling in the PVN Increases High-Fat Diet Intake and Body Weight in Stressed & Non-Stressed C57BL6J Male Mice

Frontiers in Neuroscience, 2013
Chronic social stress has been associated with increased caloric intake and adiposity. These effects have been linked to stress induced changes in the secretion of ghrelin, a hormone that targets a number of brain regions to increase food intake and ...
Zachary Robert Patterson, Tamara Joelle Parno, Albert McAnsah Isaacs, Alfonso eAbizaid   +3 more
doaj   +1 more source

Neuroendocrine Regulation of Metabolism [PDF]

, 2016
Given the current environment in most developed countries, it is a challenge to maintain a good balance between calories consumed and calories burned, although maintenance of metabolic balance is key to good health. Therefore, understanding how metabolic
Becu Villalobos, D., Coirini, Hector, Cornejo, María Paula, Elias, C. F., Hentges, S.T., Maliqueo, M.   +5 more
core   +3 more sources

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers [PDF]

, 2017
Intragastric administration of the bitter tastant denatonium benzoate inhibits the increase of motilin plasma levels and antral contractility. While these findings suggest that gastrointestinal bitter taste receptors could be new targets to modulate ...
Andreozzi, Avau, Avesaat, Carlson, Chen, Chen, Code, Date, Deloose, Deloose, Dooley, Gutierrez, Hellstrom, Hofer, Janssen, Kaji, Kim, Kuroda, Miyano, Schier, Straub, Tack, Wang, Wicks, Wiener   +24 more
core   +2 more sources

Current status, trends, and controversies in the selection of gastrectomy procedures: Insights from two nationwide questionnaire surveys conducted over a 7‐year interval in Japan

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the evolving trends and challenges in gastrectomy procedures in Japan, drawing on two nationwide surveys conducted in 2014 and 2021. Results show a significant shift toward minimally invasive and function‐preserving surgeries, such as laparoscopic and robot‐assisted gastrectomy, with an emphasis on enhancing postoperative ...
Koji Nakada, Hideyuki Kashiwagi, Shinichi Kinami, Hiroharu Yamashita, Nobuyoshi Hanyu, Atsushi Oshio, Michio Kaminishi, Yasuyuki Seto   +7 more
wiley   +1 more source