Results 201 to 210 of about 2,748,395 (254)
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Hormone and Metabolic Research, 1996
This paper describes the development and characterization of the first monoclonal antibody specific for the recently cloned human glucagon receptor (hGR), and its use in probing receptor structure and function. We demonstrate specificity of one of the antibodies, CIV395.7A, by immunofluorescence staining and immunoprecipitation analysis.
J, Buggy +5 more
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This paper describes the development and characterization of the first monoclonal antibody specific for the recently cloned human glucagon receptor (hGR), and its use in probing receptor structure and function. We demonstrate specificity of one of the antibodies, CIV395.7A, by immunofluorescence staining and immunoprecipitation analysis.
J, Buggy +5 more
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Diabetes, 1997
The binding of glucagon to its hepatic receptor is known to result in a number of effects, including the intracellular accumulation of cAMP, the mobilization of intracellular Ca2+, and the endocytosis of glucagon and its receptor into intracellular vesicles.
J J, Buggy +6 more
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The binding of glucagon to its hepatic receptor is known to result in a number of effects, including the intracellular accumulation of cAMP, the mobilization of intracellular Ca2+, and the endocytosis of glucagon and its receptor into intracellular vesicles.
J J, Buggy +6 more
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Annales de biologie clinique, 1977
The lecturer recalls the discovery of glucagon receptors in liver cell membranes, the role of the adenylate cyclase-AMPc system, until recent attempts at purification and isolation of this receptor. He then reviews successively, the problems of estimation, specificity of the interaction, the effects of purine and pyrimidine nucleotides on glucagon ...
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The lecturer recalls the discovery of glucagon receptors in liver cell membranes, the role of the adenylate cyclase-AMPc system, until recent attempts at purification and isolation of this receptor. He then reviews successively, the problems of estimation, specificity of the interaction, the effects of purine and pyrimidine nucleotides on glucagon ...
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Glucagon receptor signaling in metabolic diseases
Peptides, 2018Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels and this has recently have been ...
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Diabetes, 1998
cAMP is required for normal glucose-induced insulin release by pancreatic β-cells. In a previous study, we showed that cAMP production in β-cells depends on the expression of receptors for glucagon, glucagon-like peptide 1(7-36) amide [GLP-1(7-36) amide], and glucose- dependent insulinotropic polypeptide. Although the latter two peptides are thought to
Moens, Karen +5 more
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cAMP is required for normal glucose-induced insulin release by pancreatic β-cells. In a previous study, we showed that cAMP production in β-cells depends on the expression of receptors for glucagon, glucagon-like peptide 1(7-36) amide [GLP-1(7-36) amide], and glucose- dependent insulinotropic polypeptide. Although the latter two peptides are thought to
Moens, Karen +5 more
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Glucagon receptors along the nephron: [125I]glucagon binding in rat tubules
Pfl�gers Archiv European Journal of Physiology, 1985Binding of [125I]glucagon was measured in microdissected pieces of tubules from the rat nephron. Specific glucagon binding sites were found only in nephron segments containing a glucagon-sensitive adenylate cyclase activity. At 7.5 nM labelled hormone, higher levels of specific binding (16-27 X 10(-18) mol mm-1) were found in the thick ascending limb ...
D, Butlen, F, Morel
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Glucagon-like peptide-1 receptor
Current BiologyMichael Krashes discusses glucagon-like peptide-1 receptors, their physiological role in glucose metabolism and the mode of action of their agonists that are used to treat obesity and were later shown to promote weight loss.
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Independence of Glucagon Receptors and Glucagon Inactivation in Liver Cell Membranes
Nature New Biology, 1972THERE is increasing evidence that receptors for polypeptide hormones are localized on the cell membrane. Hormone-receptor interactions have been studied primarily by measuring the bmding of 125I-labelled hormones to intact1 or broken-cell preparations2–6.
B, Desbuquois, P, Cuatrecasas
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Molecular determinants of glucagon receptor signaling
Peptide Science, 2002AbstractA 29‐amino acid polypeptide hormone, glucagon has been one of the most prolific models in the study of hormone action. The key biologic function of glucagon is to counterbalance the actions of insulin and maintain a normal level of serum glucose.
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The glucagon receptor and adenylate cyclase
Metabolism, 1975Acidic phospholipids play a critical role in the hormone activation of adenylate cyclase. Solubilized myocardial adenylate cyclase is unresponsive to glucagon and the catecholamines, two of the hormones which activate the membrane-bound enzyme. Phosphatidylserine, purified from bovine brain restored glucagon responsiveness of the solubilized adenylate ...
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