Glucagon receptor signalling – backwards and forwards [PDF]
Expert Opinion on Investigational Drugs, 2018 usc
Tongzhi, Wu +4 more
openaire +3 more sources
Modulation of β-catenin signaling by glucagon receptor activation. [PDF]
PLoS ONE, 2012 The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Activation of GCGR by glucagon leads to increased glucose production by the liver.
Jiyuan Ke +8 more
doaj +1 more source
Hypothalamically-Induced Insulin Release and its Potentiation During Oral and Intravenous Glucose Loads [PDF]
, 1984 Male Wistar rats were provided with bilateral cannulas in the lateral hypothalamic area (LHA) and cannulas in the left and right jugular vein. Freely moving rats provided in this way with cannulas were infused with transmitters in the LHA and with ...
A.B. Steffens +35 more
core +4 more sources
Glucagon-Like Peptide-1 Based Therapies: A New Horizon in Obesity Management [PDF]
Endocrinology and MetabolismObesity is a significant risk factor for health issues like type 2 diabetes and cardiovascular disease. It often proves resistant to traditional lifestyle interventions, prompting a need for more precise therapeutic strategies. This has led to a focus on
Jang Won Son, Soo Lim
doaj +1 more source
New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system
Current Issues in Pharmacy and Medical Sciences, 2023 Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate metabolism. It can cross the blood-brain barrier, and, indeed, while mostly produced in the distal small intestine and colon, it is also synthesized in the nucleus of ...
Lupina Malgorzata, Listos Joanna
doaj +1 more source
Modulating effects of RAMPs on signaling profiles of the glucagon receptor family
Acta Pharmaceutica Sinica B, 2022 Receptor activity-modulating proteins (RAMPs) are accessory molecules that form complexes with specific G protein-coupled receptors (GPCRs) and modulate their functions. It is established that RAMP interacts with the glucagon receptor family of GPCRs but
Lijun Shao +6 more
doaj +1 more source
A combined activation mechanism for the glucagon receptor
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Understanding the mechanisms of activation of G-protein–coupled receptors (GPCRs) is a major issue in biophysics and pharmacology. This is particularly true for peptide-activated class B receptors, which are more flexible and have been ...
Giulio Mattedi +3 more
semanticscholar +1 more source
Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells
Cell Reports, 2016 In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during metabolic challenges such as those associated with pregnancy or high-fat diet.
Joana Almaça +7 more
doaj +1 more source
In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]
, 2011 Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R. +11 more
core +2 more sources
Diabetes, 2012 Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of “indigestible” prebiotics to short-chain fatty acids (SCFAs), which in turn modulate the release of
G. Tolhurst +9 more
semanticscholar +1 more source