Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Nature Communications, 2019 Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic ...
E. Vergari +19 more
semanticscholar +1 more source
Glucagon Receptor Signaling and Lipid Metabolism [PDF]
Frontiers in Physiology, 2019 Glucagon is secreted from the pancreatic alpha cells upon hypoglycemia and stimulates hepatic glucose production. Type 2 diabetes is associated with dysregulated glucagon secretion, and increased glucagon concentrations contribute to the diabetic hyperglycemia.
Katrine D. Galsgaard +11 more
openaire +5 more sources
Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance
Molecular Metabolism, 2015 Objective: Glucagon receptor antagonists and humanized glucagon antibodies are currently studied as promising therapies for obesity and type II diabetes.
Mar Quiñones +6 more
doaj +1 more source
Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes
Frontiers in Endocrinology, 2022 Neurotransmitters are signaling molecules secreted by neurons to coordinate communication and proper function among different sections in the central neural system (CNS) by binding with different receptors.
Xiaohui Pan +5 more
doaj +1 more source
Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]
, 1984 The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Damsma, G., +3 more
core +1 more source
Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.
JCI Insight, 2019 Glucagon, a hormone released from pancreatic alpha-cells, plays a key role in maintaining proper glucose homeostasis and has been implicated in the pathophysiology of diabetes.
Lu Zhu +12 more
semanticscholar +1 more source
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner +13 more
core +2 more sources
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Glucagon stimulates hepatic glucose production by activating specific glucagon receptors in the liver, which in turn increase hepatic glycogenolysis as well as gluconeogenesis and ureagenesis from amino acids.
Etienne Larger +10 more
doaj +1 more source
Intestinal gene expression in pigs: effects of reduced feed intake during weaning and potential impact of dietary components [PDF]
, 2011 The weaning transition is characterised by morphological, histological and microbial changes, often leading to weaning-associated disorders. These intestinal changes can partly be ascribed to the lack of luminal nutrition arising from the reduced feed ...
Bauer, E. +3 more
core +1 more source
Selective loss of adipose cell responsiveness to glucagon with growth in the rat
Journal of Lipid Research, 1972 In isolated fat cells, the same maximal rate of glycerol production can be induced by epinephrine or ACTH, alone or in combination with each other or with glucagon.
Vincent Manganiello, Martha Vaughan
doaj +1 more source