Results 211 to 220 of about 147,749 (309)

Uncovering the role of genetic polymorphisms in cervical insufficiency

International Journal of Gynecology &Obstetrics, EarlyView.
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kallirhoe Kalinderi, Michail Kalinderis, Maria Chatzidimitriou, Liana Fidani   +3 more
wiley   +1 more source

Update on Medical Treatment of Cushing's Syndrome. [PDF]

Drugs
Dillon BR, Agrawal N, Schwarz Y, Dancel-Manning K, Tabarin A, Lacroix A, Hofland LJ, Feelders RA.   +7 more
europepmc   +1 more source

Four Pharmacogenomic Variants Strongly Linked to Corticosteroid‐Induced Avascular Necrosis in Children with Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract Corticosteroids are effective anti‐cancer agents for treating hematologic malignancies in children. However, avascular necrosis (AVN) is a common and debilitating adverse effect, leading to bone death and impacting long‐term quality of life. This study aimed to uncover the genetic factors contributing to corticosteroid‐induced AVN in a well ...
Miguel Cordova‐Delgado, Erika N. Scott, Shahrad R. Rassekh, Catrina M. Loucks, Wan‐Chun Chang, Edward J. Raack, Jessica N. Trueman, Colin J. D. Ross, Bruce C. Carleton, the Canadian Pharmacogenomics Network for Drug Safety Consortium   +9 more
wiley   +1 more source

The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia. [PDF]

J Biol Chem
Chang M, Zhao M, Whang EM, Lee RA, Scott DK, Wang JC.   +5 more
europepmc   +1 more source

Clinical and Biochemical Factors Associated With Infliximab Pharmacokinetics in Adult Patients With Inflammatory Bowel Disease

The Journal of Clinical Pharmacology, EarlyView.
Abstract Many patients with inflammatory bowel disease (IBD) do not adequately respond to infliximab, potentially due to individual differences in pharmacokinetics (PK). This study aimed to identify clinical and biochemical variables associated with infliximab PK.
Ilse A. Pool, Ilse Volkerink, Mirthe Stavast, Jos G. W. Kosterink, Gerard Dijkstra, Paola Mian, Arno R. Bourgonje   +6 more
wiley   +1 more source

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt, Kirsteen M. Donaldson, Jeevan R. Kunta, Joseph M. Custodio   +3 more
wiley   +1 more source

The Therapeutic Effects of Purified Cortrophin Gel on Experimental Autoimmune Uveitis. [PDF]

Ocul Immunol Inflamm
Taylor AW, Kim M, Zhao JL, Ng TF.
europepmc   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Evaluation of Endocrine Disruptome and VirtualToxLab for Predicting Per- and Polyfluoroalkyl Substances Binding to Nuclear Receptors. [PDF]

J Xenobiot
Franko N, Vetrih M, Sollner Dolenc M.
europepmc   +1 more source

The Etiological Role of Impaired Neurogenesis in Schizophrenia: Interactions with Inflammatory, Microbiome and Hormonal Signaling. [PDF]

Int J Mol Sci
So MT, Ullah A, Waris A, Alhumaydhi FA.
europepmc   +1 more source