Results 231 to 240 of about 147,749 (309)

Computational simulations of endocrine bone diseases related to pathological glandular PTH secretion using a multi-scale bone cell population model. [PDF]

Front Bioeng Biotechnol
Modiz C, Castoldi NM, Scheiner S, Martínez-Reina J, Calvo-Gallego JL, Sansalone V, Martelli S, Pivonka P.   +7 more
europepmc   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Identification and verification of hub biomarkers and immune-related pathways participating in the trabecular meshwork after using corticosteroid. [PDF]

PLoS One
Wang L, Wu D, Ma Z, Song D, Sun Y, Pan X, Zhang J.   +6 more
europepmc   +1 more source

Effects of Genistein on Inflammasome Induced Pancreatic β‐Cell Apoptosis by Dexamethasone

Molecular Nutrition &Food Research, EarlyView.
The possible mechanism of genistein‐mediated protection against dexamethasone‐induced pancreatic β‐cell apoptosis. Genistein decreases the activation of IRE‐1α, resulting in the reduction of sXBP1, JNK, TXNIP, NLRP3, and IL‐1β expression. Genistein inhibits dexamethasone‐induced pancreatic β‐cell apoptosis.
Nattinee Jitprawet, Jatuporn Sujjitjoon, Petcharee Maneethorn, Namoiy Semprasert, Suwattanee Kooptiwut   +4 more
wiley   +1 more source

The Role of the SLC1A5 Transporter on Glutathione Homeostasis and Enterocyte Apoptosis in Chronic Treatment of Rats with Immunosuppressive Drugs. [PDF]

Int J Mol Sci
Wawrowski T, Surówka A, Żołnierczuk M, Prowans P, Grabowska M, Kupnicka P, Markowska M, Kaczmarkiewicz M, Sych W, Zagrodnik E, Kędzierska-Kapuza K.   +10 more
europepmc   +1 more source

Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health

Molecular Nutrition &Food Research, EarlyView.
This review highlights the emerging connection between paternal nutrition‐induced sperm epigenetic changes and placental phenotypes that may influence offspring metabolic health. An accompanying interactive ShinyApp allows exploration of these sperm–placenta gene networks, a framework for future research seeking to explore candidate biomarkers or ...
David A. Skerrett‐Byrne, Anne‐Sophie Pepin, Katharina Laurent, Johannes Beckers, Robert Schneider, Martin Hrabě de Angelis, Raffaele Teperino   +6 more
wiley   +1 more source

Lipid Hormones at the Intersection of Metabolic Imbalances and Endocrine Disorders. [PDF]

Curr Issues Mol Biol
Dobre MZ, Virgolici B, Cioarcă-Nedelcu R.   +2 more
europepmc   +1 more source

A failed transplant

Journal of Hospital Medicine, EarlyView.
David L. Curtis
wiley   +1 more source

Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal‐Weight Rats, Prevented by Perinatal Leptin Intake

Molecular Nutrition &Food Research, EarlyView.
Early‐life exposure of rats to high‐fat‐isocaloric diet leads to metabolically obese, normal‐weight phenotype, and impaired cognition. Hippocampal transcriptomic analysis reveals disruption in pathways linked to obesity and cognitive decline, which is mitigated by perinatal leptin supplementation. PBMC share common altered genes with hippocampus, which
Carmen García‐Ruano, Andrea Costa, Andreu Palou, Paula Oliver   +3 more
wiley   +1 more source