Results 261 to 270 of about 151,397 (309)

Glucocorticoid Receptor Antagonists

Current Topics in Medicinal Chemistry, 2008
This review covers recent progress in the discovery of selective glucocorticoid receptor (GR) antagonists. Potential therapeutic applications of selective GR antagonists are described including the pharmacological rationale and, in some cases, clinical evidence that underlies these proposed uses. Disease areas that are discussed are Cushing's syndrome,
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Glucocorticoid receptor regulation

Life Sciences, 1985
Glucocorticoids, like other classes of steroid hormones, must bind to cellular receptors in order to exert their effects. Because of this central role in mediating hormone action, it is important to elucidate those factors that control receptor content.
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The human glucocorticoid receptor

2023
Glucocorticoids are members of steroid hormones that are biosynthesized in the intermediate cellular zone of the adrenal cortex (zona fasciculata) and released into the peripheral blood as final products of the hypothalamic-pituitary-adrenal (HPA) axis, as well as under the control of the circadian biologic system.
Nicolas C, Nicolaides, George P, Chrousos   +1 more
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Selective Glucocorticoid Receptor Ligands

Medicinal Chemistry, 2007
Glucocorticoids are four-ring steroid compounds that regulate a wide range of physiological systems ranging from embryonic respiratory development, immune function and responses to acute or chronic stress. Glucocorticoids are taken up by many target cells where they bind and activate cytoplasmic glucocorticoid receptors (GRs), which then dimerize ...
Timothy J, Cole, Richard, Mollard
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Chaperoning of Glucocorticoid Receptors

2005
A multiprotein hsp90/hsp70-based chaperone machinery functions as a 'cradle-to-grave' system for regulating the steroid binding, trafficking and turnover of the glucocorticoid receptor (GR). In an ATP-dependent process where hsp70 and hsp90 act as essential chaperones and Hop, hsp40, and p23 act as nonessential co-chaperones, the machinery assembles ...
W B, Pratt, Y, Morishima, M, Murphy, M, Harrell   +3 more
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Genetics of glucocorticoid receptors

Molecular and Cellular Endocrinology, 1986
The lymphocytolytic effect of glucocorticoids has been used for isolating receptor mutants. They fall into several groups with defects either in the hormone binding domain or the DNA binding domain or with part of the receptor polypeptide missing. These truncated receptors have increased binding affinity for general DNA and are synthesized from 5 ...
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Selective Glucocorticoid Receptor modulators

The Journal of Steroid Biochemistry and Molecular Biology, 2010
The ancient two-faced Roman god Janus is often used as a metaphor to describe the characteristics of the Glucocorticoid Receptor (NR3C1), which exhibits both a beneficial side, that serves to halt inflammation, and a detrimental side responsible for undesirable effects. However, recent developments suggest that the Glucocorticoid Receptor has many more
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The Glucocorticoid Receptor

2010
Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
Robert H. Oakley, John A. Cidlowski
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Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

Nature, 2021
Chunyou Mao, Peng Xiao, Yi Jiang
exaly  

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

Nature Reviews Endocrinology, 2022
Carolyn L Cummins
exaly