Results 81 to 90 of about 2,388,695 (167)
Proceedings of the National Academy of Sciences of the United States of America, 1981 Activated glucocorticoid receptor protein, purified to 40-60% homogeneity from rat liver extracts, binds selectively in vitro to a cloned fragment of murine mammary tumor virus (MTV) DNA.
F. Payvar +5 more
semanticscholar +1 more source
Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]
Science's STKE (electronic resource) : signal transduction
knowledge environment 327 (21/03/2006) 13, 2007 Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv
Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
Nature, 2021 Y. Ping +24 more
semanticscholar +1 more source
Journal of Biological Chemistry, 1996 The nuclear receptors constitute a large family of transcription factors characterized by a well conserved DNA-binding domain. The receptors for glucocorticoids, progestins, mineralocorticoids, and androgens constitute a subgroup because they bind in ...
F. Claessens +5 more
semanticscholar +1 more source
Causal Mediation Analysis for Sparse and Irregular Longitudinal Data [PDF]
arXiv, 2020 Causal mediation analysis seeks to investigate how the treatment effect of an exposure on outcomes is mediated through intermediate variables. Although many applications involve longitudinal data, the existing methods are not directly applicable to settings where the mediator and outcome are measured on sparse and irregular time grids.
arxiv
Journal of Biological Chemistry, 2000 The basis for specificity of gene regulation by steroid hormone receptors remains an important problem in the study of steroid hormone action. One possible mechanism for steroid specificity is the difference in DNA binding characteristics of the ...
E. Schoenmakers +5 more
semanticscholar +1 more source
Context Modulates Outcome of Perinatal Glucocorticoid Action in the Brain
Frontiers in Endocrinology, 2014 Prematurely born infants may be at risk, because of inadequate maturation of tissues. If there are signs of preterm birth, it has become common practice therefore to treat either antenatally the mother or postnatally the infant with glucocorticoids to ...
Edo Ronald ede Kloet +2 more
doaj +1 more source
Accuracy of direct gradient sensing by cell-surface receptors [PDF]
arXiv, 2009 Chemotactic cells of eukaryotic organisms are able to accurately sense shallow chemical concentration gradients using cell-surface receptors. This sensing ability is remarkable as cells must be able to spatially resolve small fractional differences in the numbers of particles randomly arriving at cell-surface receptors by diffusion.
arxiv
DiseasesChronic stress is a significant factor affecting modern society, with profound implications for both physical and mental health. Central to the stress response is cortisol, a glucocorticoid hormone produced by the adrenal glands.
Aleksandar Sic +3 more
doaj +1 more source
Chemical sensing by cell-surface chemoreceptor arrays: the roles of receptor cooperativity and adaptation [PDF]
arXiv, 2012 Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing.
arxiv