Results 201 to 210 of about 310,321 (241)

The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity. [PDF]

Sci Rep
Khadrawy YA, Khoder NM, El-Gizawy MM, Hosny EN, Sawie HG, Elkholy NS, Amer HM, Ezz HSA.   +7 more
europepmc   +1 more source

Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing [PDF]

, 2019
Huettner, James E, Wilding, Timothy J
core   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Glutamate-associated research in Parkinson's disease: a bibliometric analysis. [PDF]

Front Aging Neurosci
Chen YJ, Xie MR, Zhou SQ, Liu F.
europepmc   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Type 3 Diabetes: Linking Insulin Resistance to Cognitive Decline. [PDF]

Diseases
Chapple B, Bayliss E, Woodfin S, Smith M, Winter J, Moore W.   +5 more
europepmc   +1 more source

Orofacial antinociceptive effect of a novel 2-amino-thiophene derivative and its possible targets of action. [PDF]

Braz Oral Res
Silva AJD, Silva PRD, Pires HFO, Dias AL, Felipe CFB, Mendonça-Junior FJB, Nayarisseri A, Alves AF, Scotti MT, Golzio AMFO, Castro RD.   +10 more
europepmc   +1 more source

Subarachnoid hemorrhage mediates human neocortical network, membrane potential, and action potential bursting via glutamate receptors. [PDF]

Commun Biol
Huang DF, Chou MY, Lee YH, Chen YT, Sun CK, Wang KC, Huang HS.   +6 more
europepmc   +1 more source

On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily

Angewandte Chemie International Edition, EarlyView.
Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Lukas Drexler, Torben F. Fürtges, Till Rudack, Reinhard Sterner   +3 more
wiley   +1 more source

Losing the Filter: How Kynurenine Pathway Dysregulation Impairs Habituation. [PDF]

Cells
de la Flor MA, O'Connor JC.
europepmc   +1 more source